Incidence & Outcomes of SSI After Breast Cancer Surgery

发生率

• 批准号: 7276645
• 负责人: MARGARET A OLSEN
• 金额: $ 9.54万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276645
• 关键词: Adjuvant Therapy; Ambulatory Care Facilities; Antibiotic Resistance; Antibiotics; Biometry; Breast; Breast-Conserving Surgery; Clinical; Communicable Diseases; Comorbidity; Data; Databases; Development; Economics; Goals; Healed; Health; Health behavior; Hospitalization; Hospitals; Incidence; Infection; Infection Control; Infection prevention; Inpatients; Intervention; K-Series Research Career Programs; Knowledge; Mammaplasty; Mastectomy; Measures; Medical Surveillance; Mentors; Nosocomial Infections; Operative Surgical Procedures; Outcome; Outcomes Research; Outpatients; Patients; Persons; Population; Range; Rate; Reporting; Research; Risk; Risk Factors; Sex Functioning; Site; Statistical Models; Stratification; Surgical incisions; System; Time; Training; Training and Education; United States; Visit; Woman; breast surgery; cancer surgery; cohort; cost; demographics; depressive symptoms; design; epidemiology study; follow-up; follower of religion Jewish; healing; health related quality of life; indexing; malignant breast neoplasm; multidisciplinary; prospective; reconstruction; skills

DESCRIPTION (provided by applicant): This Career Development Award (K01) is a proposal to further my education and training in advanced biostatistics, econometrics, and health outcomes research through didactic courses and contact with a primary mentor and multidisciplinary group of experts in diverse fields ranging from infectious diseases to economics and health behavior research. The goal of this advanced training is to acquire the knowledge and skills necessary to comprehensively study the epidemiology and outcomes of surgical site infections (SSI) after breast cancer surgery, that may impact as many as 18,000 women each year in the United States. A prospective longitudinal cohort design will be used to determine accurate incidences and risk factors for SSI within 1 year after breast-conserving surgery, mastectomy, and mastectomy with immediate reconstruction. Clinical outcomes of SSI, including consequent further surgical interventions, antibiotic administration, and development of antibiotic resistance will be measured utilizing inpatient and outpatient follow-up data. The impact of SSI on overall health-related quality of life, depressive symptoms, sexual functioning, and specific issues related to the healing breast incision will be assessed multiple times after surgery. From the societal perspective, the economic costs attributable to SSI following the different types of breast surgery will be quantified using financial data obtained from inpatient hospitalizations and outpatient clinic visits. The advanced training received in biostatistics will allow for the creation of detailed statistical models to calculate the attributable costs of SSI in both the inpatient and outpatient setting. Determining accurate incidences and identification of specific risk factors for development of SSI in this surgical population will facilitate the development of risk stratification indices and infection control interventions to prevent these infections following breast cancer surgery.

描述（由申请人提供）：这个职业发展奖（K01）是一个建议，以进一步我的教育和培训，在先进的生物统计学，计量经济学，和健康结果的研究，通过教学课程和接触的主要导师和多学科专家组在不同领域，从传染病到经济学和健康行为研究。这项高级培训的目标是获得必要的知识和技能，以全面研究乳腺癌手术后手术部位感染（SSI）的流行病学和结果，这可能影响美国每年多达18，000名妇女。将采用前瞻性纵向队列设计确定保乳手术、乳房切除术和乳房切除术伴即刻再造后1年内SSI的准确发生率和风险因素。SSI的临床结局，包括随后的进一步手术干预、抗生素给药和抗生素耐药性的发展，将利用住院和门诊随访数据进行测量。手术后将多次评估SSI对整体健康相关生活质量、抑郁症状、性功能以及与愈合乳房切口相关的特定问题的影响。从社会角度来看，将使用从住院和门诊就诊获得的财务数据量化不同类型乳房手术后SSI的经济成本。在生物统计学方面接受的高级培训将允许创建详细的统计模型，以计算住院和门诊环境中SSI的可归因成本。在该手术人群中确定准确的发生率并识别发生SSI的特定风险因素，将有助于制定风险分层指数和感染控制干预措施，以预防乳腺癌手术后的感染。