Training in Molecular Physics of Biological Systems

描述(由申请者提供)：项目摘要：康奈尔大学的分子生物物理学培训资助计划提供了结合物理和生物科学的强有力的跨学科培训。被选中参加培训的学生可能拥有物理或生物科学的本科学位，并必须被康奈尔大学研究生院录取，以获得25个参与教职的研究生领域的博士学位，其中包括：物理、应用物理、化学和化学生物学、生物化学、分子和细胞生物学、计算科学、神经生物学和行为学、营养学、药理学和生物物理学。该计划每年支持12名学员，每个人的总支持期限为2-3年。学员通过数学、量子力学、统计热力学、生物化学和分子生物学、计算和仪器仪表等高级课程进行跨学科研究，以及其他专题。论文研究和参与教员实验室的合作为分子生物物理学的教学和跨学科研究生涯做好了充分的准备。参与的教职员工与康奈尔大学完善的、不断发展的生物物理学计划有关，该计划为本培训计划提供了重点。分子生物物理学的研究机会包括：使用理论方法调查蛋白质和其他大分子的结构和功能；用同步辐射X射线结晶学、电子自旋共振光谱和多维核磁共振确定结构；研究分子马达；细胞膜、受体和神经递质的结构和分子机制以及相关的细胞功能；材料和技术的开发，包括非线性激光显微镜、稳态和时间分辨光谱和成像；单通道记录；光学镊子；纳米制造；以及通过合作和中心设施，上述许多组合。计算机能力，联网，在线，并在康奈尔理论中心达到顶峰，扩展了分子生物物理学研究和教育的一系列设施。康奈尔大学为成功和富有成效的分子生物物理培训补助金的持续增长提供了理想的基础设施。相关性：受训人员将参加的所有项目都旨在解决对公共卫生具有重要意义的生物医学问题。特别是，这个项目的目标是训练学生将强大的物理和化学技术应用于与医学相关的问题。这将导致设计新的药物疗法，识别药物治疗的新细胞和分子靶点，更好地了解与疾病有关的细胞成分，以及新的诊断程序(特别是非侵入性程序)。

DESCRIPTION (provided by applicant): Project summary: Cornell's Molecular Biophysics Training Grant Program offers vigorous interdisciplinary training that combines physical and biological sciences. The trainees selected to participate may have undergraduate degrees in either physical or biological sciences and must have been admitted to the Graduate School at Cornell for training leading to the Ph.D. in one of the Graduate Fields of the twenty-five participating faculty including: Physics, Applied Physics, Chemistry and Chemical Biology, Biochemistry, Molecular and Cell Biology, Computing Science, Neurobiology and Behavior, Nutrition, Pharmacology and Biophysics. The program is designed to support 12 trainees each year, with a total duration of support for each individual at 2-3 years. Trainees undertake interdisciplinary studies with advanced courses in mathematics, quantum mechanics, statistical thermodynamics, biochemistry and molecular biology, computation and instrumentation, and other special topics. Thesis research and collaborations in the laboratories of the participating faculty complete preparation for a career of teaching and interdisciplinary research in molecular biophysics. The participating faculty members are associated with Cornell's well established and continuously growing Biophysics Program which provides the focus for this training program. Research opportunities in molecular biophysics include investigation of structure and function of proteins and other macromolecules using theoretical approaches, structure determination by synchrotron X-ray crystallography, electron spin resonance spectroscopy, and multidimensional NMR; studies of molecular motors; structures and molecular mechanisms of cell membranes, receptors, and neurotransmitters and associated cellular functions; materials and technology developments including nonlinear laser microscopy, steady-state and time resolved spectroscopy and imaging; single channel recording; optical tweezers; nanofabrication; and through collaborations and Center facilities, many combinations of the above. Computer capabilities, networked, on-line and culminating in the Cornell Theory Center extend the array of facilities for research and education in molecular biophysics. Cornell provides the ideal infrastructure for continued growth of the successful and productive Molecular Biophysics Training Grant. Relevance: All of the projects in which trainees will participate are designed to address biomedical problems of importance to public health. In particular, the goal of this program is to train students to apply the powerful techniques of physics and chemistry to problems of medical relevance. This will lead to the design of new drug therapies, the identification of new cellular and molecular targets for drug therapy, a better understanding of the cell components involved in diseases, and new diagnostic procedures (particularly, noninvasive procedures).