Cyclotron for biomedical research

用于生物医学研究的回旋加速器

• 批准号: 7498324
• 负责人: Chaitanya R. Divgi
• 金额: $ 200万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498324
• 关键词: Animal Experimentation; Animals; Biochemical; Biomedical Research; Clinical Research; Communities; Cyclotrons; Development; Diagnostic; Discipline; Ensure; Generations; Growth; Human; Invasive; Isotopes; Measures; Numbers; Pennsylvania; Physiological; Positron; Pre-Clinical Model; Process; Production; Public Health; Radioisotopes; Rate; Research; Research Personnel; Translating; Translational Research; United States National Institutes of Health; Universities; analytical tool; imaging probe; in vivo; insight; instrument; molecular imaging; novel; pre-clinical; programs; radiotracer; research study; tool

DESCRIPTION (provided by applicant): We request a third generation cyclotron to meet current research demands and expand application of accelerator-produced radionuclides. The instrument will increase our ability to produce radiotracers for the broader scientific community. Many researchers throughout the University of Pennsylvania, who receive considerable support from the NIH, have recognized the opportunities molecular imaging presents as a non-invasive analytical tool for measuring biochemical and physiological phenomena in vivo. Demand has significantly increased and continues to grow; our cyclotron, procured with NIH support in 1985, has reached capacity. The molecular imaging program at Penn has grown substantially; numerous radiotracers are being synthesized for pre-clinical and clinical research. We have an active Imaging Probe Synthesis Core for human and animal research, which relies heavily on timely and sufficient production of adequate quantities of radionuclides. We also have successfully translated a number of promising radiotracers through pre-clinical models into clinical research studies. However, our current ability to produce amounts of radiotracers in adequate amounts has been rate-limiting to translational research. Progress necessitates a modern facility that will enable production of novel positron emitters in quantities not feasible with the current cyclotron. The proposed instrument will ensure sufficient radionuclide and radiotracer production to support the growth in our molecular imaging program and thus substantially enhance ongoing research; increase the ability to pursue proof-of-principle research; effect a substantial impact in molecular imaging within a multitude of disciplines, and allow the existing cyclotron to be exploited for novel isotope development. PUBLIC HEALTH RELEVANCE: Our translational research program in molecular imaging has provided key insights into biologic processes in both animal studies and in clinical research. For continued growth, we need a new cyclotron, which will allow us to increase production, resulting in new radiotracers that increase scientific understanding and ultimately provide clinicians with unique diagnostic tools.

描述（由申请人提供）：我们要求第三代回旋子满足当前的研究需求并扩大加速器生产的放射性核素的应用。该工具将提高我们为更广泛的科学界生产放射性示例的能力。宾夕法尼亚大学的许多研究人员都从NIH获得了大量支持，他们认识到机会分子成像是一种非侵入性的分析工具，用于测量体内生化和生理现象。需求已大大增加并继续增长；我们的回旋子于1985年获得了NIH支持，已达到能力。宾夕法尼亚州的分子成像程序已经大大发展。正在合成许多放射性示例，用于临床前和临床研究。我们为人类和动物研究具有主动的成像探针合成核心，该核心在很大程度上取决于及时和足够的足够生产足够数量的放射性核素。我们还通过临床前模型成功地将许多有希望的放射性示例转化为临床研究。但是，我们目前生产足够数量的放射性示例量的能力已限制转化研究。进步需要一个现代化的设施，该设施将能够以当前的回旋子不可行的数量生产新的正电子发射器。该提出的仪器将确保足够的放射性核素和放射性示踪剂的产生，以支持我们的分子成像程序的生长，从而大大增强正在进行的研究。提高追求原理研究的能力；影响许多学科中分子成像的实质性影响，并允许现有的回旋子被利用以进行新型同位素发展。 公共卫生相关性：我们在分子成像方面的转化研究计划为动物研究和临床研究中的生物学过程提供了重要的见解。为了持续增长，我们需要一个新的回旋器，这将使我们能够增加产量，从而导致新的放射性示例增加科学理解，并最终为临床医生提供独特的诊断工具。