3 Tesla Magnetic Resonance Imaging for Studies of Child Development and Disorders

描述(由申请人提供)：这份S10共享仪器拨款申请申请金额为500,000美元，用于购买辛辛那提儿童研究基金会(CCRF)用于儿科成像研究的专用3特斯拉磁共振扫描仪。这些资金将得到超过300万美元的机构资金的补充，以全面装备成像研究中心(IRC)现有的3THead Only MRI扫描仪(现已有15年历史)的现代替代品。作为儿科领先的成像研究项目之一，IRC将利用建议的仪器和我们在儿科成像方面的现有专业知识，继续领导儿童发育和疾病的翻译成像研究。IRC将继续使用建议的系统在儿科健康研究的关键领域做出贡献，包括语言发育、听力损失、青少年关节炎、肌营养不良、心脏异常、代谢性脑障碍、精神和行为脑障碍、创伤性脑损伤和癫痫的研究。 这份S10提案所要求的核磁共振扫描仪将用于调查儿科疾病和发育障碍，并将促进IRC作为CCRF发育生物学和临床儿科学研究人员的核心资源在下一个十年发挥作用。作为美国国立卫生研究院资助的专注于儿科医学研究的三大研究机构之一，CCRF在呼吸道和自身免疫性疾病以及遗传综合征和疫苗的治疗方法的发现和开发方面发挥了领先的影响。在CCHMC安装现代成像设施是对NCRR资源的极好投资，并可能对改善儿童健康产生最大可能的影响。

DESCRIPTION (provided by applicant): This S10 Shared Instrument grant application requests $500,000 toward the purchase of a research dedicated 3 Tesla MRI scanner for use in pediatric imaging research at Cincinnati Children's Research Foundation (CCRF). These funds will be complemented by institutional funds in excess of $3M, to fully equip the Imaging Research Center (IRC) with a modern replacement for it's existing 3T head only MRI scanner (now 15 years old). As one of the leading imaging research programs in pediatrics, the IRC will use the proposed instrument and our existing expertise in pediatric imaging to continue to lead translational imaging research in child development and disease. Key areas in pediatric health research in which the IRC will continue to contribute using the proposed system include the study of language development, hearing loss, juvenile arthritis, muscular dystrophy, cardiac abnormalities, metabolic brain disorders, psychiatric and behavioral brain disorders, traumatic brain injury, and epilepsy. The MRI scanner requested with this S10 proposal will be used to investigate pediatric diseases and developmental disorders and will facilitate the role of the IRC as a core resource for researchers in developmental biology and clinical pediatrics at CCRF for another decade. As one of the top three NIH funded research institutions focusing on pediatric medical research CCRF has been a leading influence in the discovery and development of treatments for respiratory and autoimmune diseases as well as genetic syndromes and vaccines. Installation of modern imaging facilities at CCHMC represents and excellent investment of NCRR resources and is likely to have the greatest possible impact on improving child health.