MBRS Support of Continuous Research Excellence at FAU

MBRS 对 FAU 持续卓越研究的支持

• 批准号: 7448462
• 负责人: RAMASWAMY NARAYANAN
• 金额: $ 70.14万
• 依托单位: FLORIDA ATLANTIC UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-08 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7448462
• 关键词: Anabolism; Applied Research; Area; Biochemistry; Biological Sciences; Biomedical Research; Bioterrorism; Calculi; Cardiomyopathies; Chemistry; Communities; County; Cultural Diversity; Development; Diet; Education; Educational process of instructing; Employment Opportunities; Environment; Faculty; Florida; Human Resources; Institution; Lipids; Microbiology; Minority-Serving Institution; Neurons; Numbers; Oxidative Stress; Population Heterogeneity; RNA; Raman Spectrum Analysis; Research; Research Personnel; Restart; Science; Score; Services; Signal Transduction; Sjogren' s Syndrome; Students; System; Training; Tumor Cell Invasion; Underrepresented Minority; United States; Universities; career; college; novel therapeutics; programs

DESCRIPTION (provided by applicant): As one of the fastest growing Universities in the United States, Florida Atlantic University (FAU) recognizes the need to serve a diverse population. Situated in South Florida, a multi-cultural environment, FAU draws many of its students from the local community. As the higher education needs of the underrepresented minorities in the area grow, they will likely turn more and more to FAU to service those needs. To that end, FAU would like to develop competitive research programs that increase the number of underrepresented minorities professionally engaged in biomedical research. FAU is the most ethnically diverse institution in the State of Florida. The University community has more than 25,000 students and 900 faculty. Through its 8 colleges, FAU offers more than 170 baccalaureate, master's, and doctoral degree programs and conducts basic and applied research. Biomedical sciences is one of FAU's strategic themes, with a commitment to quality and cultural diversity. The FAU focus on biomedical sciences is represented by the 14 subprojects and 6 pilot subprojects in the present proposal. The research encompasses the Departments of Chemistry and Biochemistry, Biomedical Science, and Biological Sciences, and includes the synthesis or biosynthesis and characterization of novel therapeutics, understanding the basic mechanisms of tumor cell invasion, Sjogren's syndrome, cardiomyopathies, neuron survival in the olfactory system, RNA damage during oxidative stress, and lipid signaling in diet, microbiology/bioterrorism, and development of resonance Raman spectroscopy as a cellular probe. The majority of the investigators are junior faculty, and the SCORE Program would provide a tremendously important stepping stone in their research careers. For the more senior investigators, the Program would allow them to pursue new research areas or restart projects that had been slowed by substantial teaching assignments. The training of personnel would be substantial, and critical given the influx of biomedical employment opportunities to Palm Beach County. The MBRS SCORE Program would facilitate faculty development and training in all areas of biomedical research at a major minority serving institution.

描述（由申请人提供）：作为美国发展最快的大学之一，佛罗里达大西洋大学（FAU）认识到需要为多样化的人口服务。FAU位于南佛罗里达，一个多元文化的环境，吸引了许多来自当地社区的学生。随着该地区代表性不足的少数民族的高等教育需求的增长，他们可能会越来越多地转向FAU来满足这些需求。为此，FAU希望制定有竞争力的研究计划，增加专业从事生物医学研究的代表性不足的少数民族的数量。 FAU是佛罗里达州种族最多元化的机构。大学社区有超过25，000名学生和900名教师。通过它的8个学院，FAU提供超过170个学士学位，硕士和博士学位课程，并进行基础和应用研究。生物医学科学是FAU的战略主题之一，致力于质量和文化多样性。本建议书中的14个分项目和6个试点分项目体现了FAU对生物医学科学的关注。该研究包括化学和生物化学，生物医学科学和生物科学的部门，并包括合成或生物合成和表征的新疗法，了解肿瘤细胞侵袭的基本机制，干燥综合征，心肌病，嗅觉系统中的神经元存活，氧化应激过程中的RNA损伤，以及饮食中的脂质信号，微生物学/生物恐怖主义，以及共振拉曼光谱作为细胞探针的发展。大多数研究人员是初级教师，SCORE计划将为他们的研究生涯提供非常重要的垫脚石。对于更资深的研究人员，该计划将允许他们追求新的研究领域或重新启动因大量教学任务而放缓的项目。鉴于生物医学就业机会大量涌入棕榈滩海滩县，人员培训将是实质性的，而且至关重要。MBRS SCORE计划将促进主要少数民族服务机构生物医学研究所有领域的教师发展和培训。

项目成果

Insights into restrictive cardiomyopathy from clinical and animal studies.

• DOI: 10.3724/sp.j.1263.2011.00168
• 发表时间: 2011-09
• 期刊: Journal of geriatric cardiology : JGC
• 作者: Jean-Charles PY;Li YJ;Nan CL;Huang XP
• 通讯作者: Huang XP

Solid-phase synthesis of fusaricidin/LI-F class of cyclic lipopeptides: Guanidinylation of resin-bound peptidyl amines.

• DOI: 10.1002/bip.22186
• 发表时间: 2013-04
• 期刊: BIOPOLYMERS
• 影响因子: 2.9
• 作者: Bionda, Nina;Pitteloud, Jean-Philippe;Cudic, Predrag
• 通讯作者: Cudic, Predrag

Cyclic lipodepsipeptides: a new class of antibacterial agents in the battle against resistant bacteria.

• DOI: 10.4155/fmc.13.86
• 发表时间: 2013-07
• 期刊: Future medicinal chemistry
• 影响因子: 4.2
• 作者: Bionda N;Pitteloud JP;Cudic P
• 通讯作者: Cudic P

Expression of c-fos mRNA in the basal ganglia associated with contingent tolerance to amphetamine-induced hypophagia.

基底神经节中 c-fos mRNA 的表达与对安非他明诱导的吞咽不足的偶然耐受性相关。

• DOI: 10.1016/j.bbr.2008.11.026
• 发表时间: 2009
• 期刊: Behavioural brain research
• 影响因子: 2.7
• 作者: Bachand,KimberleeD;Guthrie,KathleenM;Wolgin,DavidL
• 通讯作者: Wolgin,DavidL

Long-term survival of olfactory sensory neurons after target depletion.

目标耗尽后嗅觉感觉神经元的长期存活。

• DOI: 10.1002/cne.22084
• 发表时间: 2009
• 期刊: The Journal of comparative neurology
• 作者: Sultan-Styne,Krista;Toledo,Rafael;Walker,Christine;Kallkopf,Anna;Ribak,CharlesE;Guthrie,KathleenM
• 通讯作者: Guthrie,KathleenM