Pathophysiology of HIV Dementia in Women

女性艾滋病毒痴呆的病理生理学

• 批准号: 7490017
• 负责人: VALERIE WOJNA
• 金额: $ 31.49万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490017
• 关键词: AIDS Dementia Complex; Acquired Immunodeficiency Syndrome; African American; Age; Aging; Amyloid beta-Protein; Antioxidants; Area; Biological Factors; CD4 Lymphocyte Count; Caucasians; Caucasoid Race; Cause of Death; Cerebrospinal Fluid; Clinical; Comparative Study; Cross-Sectional Studies; Dementia; Development; Early Diagnosis; Epidemiology; Estrogens; Evaluation; Functional disorder; Gender; Goals; Gonadal Hormones; HIV; HIV Infections; High Risk Woman; Hispanics; Hormonal; Impaired cognition; In Vitro; Incidence; Infection; Intervention; Lipodystrophy; Mediating; Medical; Methods; Minority Groups; Mitochondria; Neurologic; Neurologic Manifestations; Neuropathogenesis; Numbers; Oxidative Stress; Patients; Pharmaceutical Preparations; Population; Pregnancy; Prevention; Progesterone; Property; Proteins; Puerto Rican; Puerto Rico; Range; Rate; Recruitment Activity; Research; Research Personnel; Role; Science; Severities; Societies; Testosterone; Therapeutic Intervention; Time; Toxic effect; United States; Universities; Viral Load result; Woman; Women' s Health; chemokine; cohort; cytokine; design; improved; innovation; male; neuropsychological; neurotoxic; protective effect; sex

DESCRIPTION (provided by applicant): The population of women with AIDS continues to increase as a consequence of changes in the epidemiology of HIV infection. Currently it is a leading cause of death amongst young women in the United States where the largest increase in incidence of HIV infection is in the African-American and Hispanic populations. HIV associated dementia (HAD) continues to be one of the major complications of AIDS and little is known about the factors that determine HAD in women. Therefore, this population poses several challenges in the evaluation of biological factors and hormonal modifiers, which can impact on the development and severity of HAD in women. At the University of Puerto Rico Medical Sciences Campus we have the unique opportunity to study Hispanic women with HIV infection. We have designed a cross sectional study that will identify HIV infected women at high risk of developing HAD and will determine if gonadal dysfuction and oxidative stress contribute to the dementia. We therefore propose to: a) recruit a cohort of HIV infected women and characterize their neurological and neuropsychological status, b) determine if gonadal hormone dysfunction is associated with HAD, and c) determine the contribution of CSF markers of oxidative stress and HAD. We have chosen these parameters since they are most amenable to therapeutic intervention. Potential drugs that could be used to correct these abnormalities are or can be made available in depot forms that could be used even in less compliant patient populations. Our long-range goal is to develop methods for the early diagnosis, prevention, and treatment of HIV Associated Dementia in the Puerto Rican women population.

描述（由申请人提供）：由于艾滋病毒感染流行病学的变化，患有艾滋病的妇女人数持续增加。目前，它是美国年轻女性死亡的主要原因，其中艾滋病毒感染率增幅最大的是非裔美国人和西班牙裔人群。 HIV 相关性痴呆 (HAD) 仍然是艾滋病的主要并发症之一，而对于女性 HAD 的决定因素却知之甚少。因此，这一人群在生物因素和激素调节剂的评估方面提出了一些挑战，这些因素可能会影响女性 HAD 的发展和严重程度。在波多黎各大学医学科学校区，我们有独特的机会研究感染艾滋病毒的西班牙裔妇女。我们设计了一项横断面研究，将识别感染艾滋病毒的女性是否有患 HAD 的高风险，并确定性腺功能障碍和氧化应激是否会导致痴呆。因此，我们建议：a) 招募一组 HIV 感染女性并表征她们的神经学和神经心理学状态，b) 确定性腺激素功能障碍是否与 HAD 相关，以及 c) 确定氧化应激和 HAD 的脑脊液标记物的贡献。我们选择这些参数是因为它们最适合治疗干预。可用于纠正这些异常的潜在药物已经或可以以储库形式提供，甚至可以用于不太顺从的患者群体。我们的长期目标是开发用于波多黎各妇女群体中艾滋病毒相关痴呆症的早期诊断、预防和治疗的方法。