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Blood pressure variability and cardiovascular disease in hemodialysis patients

血液透析患者的血压变异性与心血管疾病

基本信息

批准号：
7781850
负责人：
STEVEN BRUNELLI
金额：
$ 11.1万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7781850
关键词：
Address Animal Model Area Biochemical Blood Blood Pressure Blood Vessels Calendar Cardiovascular Diseases Cardiovascular system Chronic Clinical Clinical Investigator Condition Congestive Data Development Development Plans Dialysis patients Dialysis procedure Disease End stage renal failure Event Goals Heart Hemodialysis Hospitalization Individual Intervention Knowledge Maintenance Measures Membrane Mentors Methods Metric Morbidity - disease rate Nature Patients Pattern Pharmaceutical Preparations Philadelphia Physical Dialysis Population Prevalence Prospective Studies Purpose Randomized Rate Research Research Personnel Research Project Grants Risk Risk Factors Sampling Schedule Serum Time Treatment Protocols Variant Waxes Work cardiovascular risk factor career cohort design experience interest metropolitan mortality novel programs prospective time interval trend

项目摘要

DESCRIPTION (provided by applicant): This comprehensive five-year career development plan has a two-fold purpose: 1) to bring about the candidate's development into an independent clinical investigator through a combination of formal didactic coursework, directed mentoring and the conduct of the research project detailed within this application, 2) to render knowledge of the association between blood pressure variability (BPV) and cardiovascular (CV) disease in patients treated with hemodialysis (HD). Identification of novel and potentially reversible CV risk factors in HD patients is of paramount importance given the exceedingly high CV mortality rate in this population. Data in animal models and in non-uremic patients suggest that a potentially causal assocaiton between BPV and CV disease exists. Given both the dramatic CV burden and volatile nature of blood pressure in patients treated with HD, study of this association is compelling. The long-term goals of this line of research are: to determine if a causal association between BPV and CV disease exists in HD patients, and to develop targeted interventions aimed at reducing CV morbidity and mortality in HD patients via reductions in BPV. This line of research will serve as an ideal platform for the candidate's development into an independent investigator. The specific aims of this study are: 1) to describe the distribution of blood pressure variability in a representative sample of Philadelphia HD patients, 2) to define clinical factors that predict BPV and 3) to determine whether a causal association exists between blood pressure variability and cardiovascular mortality and hospitalization for CV disease. Given that randomization to various levels of BPV is neither possible nor ethical, a prospective cohort design was chosen. PUBLIC HEALTH RELEVANCE: Patients undergoing dialysis die from cardiovascular disease at very high rates, making identification of risk factors in this population critically important. This study is designed to examine whether one potential risk factor, variability in blood pressure over time, causes or contributes to cardiovascular disease in dialysis patients.

描述（由申请人提供）：