Measuring Health-Related Quality of Life in Older Adults with Chronic Illness

描述（由申请人提供）：准确的健康相关生活质量（HRQOL）测量是评估健康和医疗保健干预成功的关键方面。然而，心理学研究表明，基于记忆的方法，典型的HRQOL评估，往往是由外部因素，如情绪状态在评估时，并通过信息，很容易想到的偏见。本申请的目的是评估现有的基于回忆的方法HRQOL测量对两个新的工具测量HRQOL已被设计为强大的记忆偏差。具体来说，我们建议检查生态瞬时评估（EMA），它利用真实的时间措施，因此不受记忆偏差，和一个新的日记为基础的方法来衡量生活质量，日重建方法（DRM）。DRM被设计为在对记忆偏差的鲁棒性方面类似于EMA，但是负担和昂贵得多。我们打算开始在下肢骨关节炎患者（LE-OA）和健康老年人对照组中测试这些措施的有用性和有效性。 我们的目的是1）确定在老年OA人群中实施EMA和DRM测量的可行性，2）评价EMA和DRM用作HRQOL测量的有效性，3）确定基于DRM的HRQOL测量是否减少记忆偏差。为了实现这些目标，我们提出了一个纵向观察研究的两组老年人，一组LE-OA和健康对照组。所有参与者都将佩戴Actiwatches，这是一种腕表加速度计，也可以提示参与者在一天中多次回答简短的问卷。他们将戴一周，在这一周结束时，我们将我们将管理传统的基于召回的措施，询问症状和功能在同一时期。我们将在12个月后重复这一过程。 这些新方法可能对医疗保健研究人员非常有价值。DRM是一种先进的方法，比EMA方法成本低得多，负担也轻得多，但据我们所知，它尚未作为测量患者HRQOL的方法进行过测试。

DESCRIPTION (provided by applicant): Accurate health-related quality of life (HRQOL) measurement is a critical aspect of assessing health, and the success of health care interventions. However, psychological research indicates that memory-based methods, typical of HRQOL assessment, are often biased by extraneous factors, like mood state at the time of assessment and by information that comes easily to mind. The purpose of this application is to evaluate existing recall-based approaches to HRQOL measurement against two new tools for measuring HRQOL that have been designed to be robust to memory biases. Specifically, we propose to examine Ecological Momentary Assessment (EMA), which utilize real time measures and therefore are not subject to memory biases, and a new diary-based approach to measuring quality of life, the Day Reconstruction Method (DRM). The DRM is designed to be similar to EMA in terms of being robust to memory biases, but is much less burdensome and expensive. We intend to begin to test the usefulness and validity of these measures among lower extremity osteoarthritis patients (LE-OA) and in a comparison group of healthy older adults. Our aims are to 1) determine the feasibility of administering EMA and DRM measures in an older OA population, 2) evaluate the validity of EMA and DRM for use as HRQOL measures, and 3) determine whether a DRM-based HRQOL measure reduces memory bias. To achieve these aims, we propose a longitudinal observational study of two groups of older adults, a group with LE-OA and a healthy comparison group. All participants will wear Actiwatches, which are wrist watch accelerometers that can also prompt participants to respond to a short questionnaire several times throughout the day. They will wear these for one week, at the end of which we will we will administer traditional recall-based measures that ask about symptoms and function for this same period of time. We will repeat this procedure twelve months later. These new methods could prove to be extremely valuable for health care researchers. The DRM is a cutting edge methodology that is much less costly and burdensome than EMA methods but to our knowledge, it has not been tested as a method for measuring HRQOL measure in patients.