Mutant Mouse Aging Colony

许多NIA资助的研究使用啮齿动物来模拟衰老过程和与年龄相关的疾病。严格控制遗传纯度、动物的健康状况（包括无特定病原体状态）和环境变量是提供有效的动物模型以研究衰老的生物学和行为过程所必需的。转基因、基因敲除和突变小鼠显著地增加了针对正常衰老和年龄相关疾病病因学的特定问题或方面的研究。实验室之间共享基因工程和自然发生的突变小鼠模型大大增加了研究机会和新信息的产生。

Many NIA funded investigations use rodents to model aging processes and age-related diseases. Strict control of genetic purity, health ofthe animals including specific-pathogen-free status, and environmental variables is required to provide valid animal models that may be used to study the biological and behavioral processes in aging. Transgenic, knockout and mutant mice have added significantly to studies addressing specific questions or aspects of normal aging and age-related disease etiology. Sharing of genetically engineered and naturally occurring mutant mouse models between labs greatly enhances the research opportunities and generation of new information.