UPR-MHIRT 在传染病和分子生物学中的应用-猫眼课题宝

UPR-MHIRT 在传染病和分子生物学中的应用

批准号：

7447790

负责人：

GEORGE V HILLYER

金额：

$8.86万

依托单位：

UNIVERSITY OF PUERTO RICO MED SCIENCES

依托单位国家：

美国

项目类别：

财政年份：

1999

资助国家：

美国

项目状态：

已结题

起止时间：

1999-09-30 至 2011-06-30

来源：

https://reporter.nih.gov/project-details/7447790

关键词：

Absence of pain sensation Accounting Adult Advisory Committees Affect Affinity Albinism Alleles Alveolar Macrophages Amaze Anabolism Analgesics Animals Anti-Inflammatory Agents Anti-inflammatory Antigens Area Arts Australia Bacteria Biochemical Biochemistry Biogenesis Biological Assay Biological Markers Biological Models Biology Biomedical Research Biotechnology Canada Catabolism Caucasians Caucasoid Race Cells Cercopithecine Herpesvirus 1 Chemistry Chloroquine Chloroquine resistance Chromosomes Clams Clinical Collaborations Collection Communicable Diseases Communication Research Complement Complementary DNA Condition Coupled Cultured Cells DNA Data Data Analyses Dependence Developed Countries Developing Countries Development Developmental Biology Diagnostic Dirofilaria immitis Dirofilariasis Disadvantaged Disease Distant Doctor of Philosophy Drug Controls Drug Formulations Drug Metabolic Detoxication Drug resistance Drug-sensitive Echinodermata Echinostoma Education Embryo Endothelial Cells Environment Enzymes Erythrocytes European Evaluation Event Experimental Designs Facility Construction Funding Category Faculty Fasciola Fasciola hepatica Fascioliasis Flow Cytometry Fluorometry Foundations France Frequencies Funding Gas Chromatography Gene Expression Gene-Modified Generations Genes Genetic Genomic Library Genomics Giardia Giardia lamblia Glutamate-Cysteine Ligase Glutathione Glutathione S-Transferase Goals Growth Factor HIV Hair Hand Health Helminths Heme Hemoglobin Hepatica Hereditary Disease Hermanski-Pudlak Syndrome Hispanics Hospitals Human Human Genetics Image Immune response Immunity Immunobiology Immunological Diagnosis Immunology Induced Mutation Infection Inflammatory Inflammatory Response Institutes Institution International International Health Problems Island Kinetics Knowledge Laboratories Lasers Lead Learning Leishmania Letters Libraries Life Life Cycle Stages Ligand Binding Ligands Link London MSH receptor Macaca mulatta Mails Malaria Manuscripts Maps Mass Chromatography Measures Mediator of activation protein Medical Medical Students Medical center Melanins Melanosomes Mentors Methodology Methods Microbiology Minority Modeling Molecular Molecular Biology Molecular Genetics Molecular Virology Monitor Multi-Drug Resistance Multidrug Resistance Gene Mus Mutant Strains Mice Mutate National Center on Minority Health and Health Disparities Natural regeneration Netherlands Neural Crest Neural Crest Cell Neural tube Neurons Nitric Oxide Oryctolagus cuniculus Other Finding Pain Parasites Parasitic Diseases Parasitology Paris, France Participant Pathogenesis Pathology Phage Display Pharmaceutical Preparations Pharmacy Faculty Phenotype Piedra Plasmodium Plasmodium chabaudi Plasmodium falciparum Plasmodium malariae Play Policies Polymerase Chain Reaction Population Postdoctoral Fellow Preparation Prions Process Production Productivity Program Evaluation Progress Reports Protein Isoforms Proteins Proteomics Protocols documentation Protozoa Publications Publishing Puerto Rico RNA Interference Range Rate Reaction Reading Recombinants Regulation Regulator Genes Reporter Reporting Research Research Activity Research Personnel Research Training Resistance Resistance development Rest Review Literature Rodent Role SIV STLV-3 Safety Sampling Saposins Schistosomiasis Science Scotland Screening procedure Serum Sheep Sickle Cell Signal Transduction Simian T-lymphotropic virus 1 Site Skin Son Spain Standardization Starfish Stem cells Steroids Streptococcus bovis Strongyloidiasis Structure Student Selections Students Superoxide Dismutase System T-Lymphocyte Epitopes Techniques Technology Telephone Testing Time Tissues Training Training Programs Transcriptional Activation Transfection Transgenic Mice Transgenic Organisms Travel Trees Tropical Medicine Trypanosoma United States United States National Institutes of Health Universities Up-Regulation Vaccinated Vaccination Vaccines Variant Vertebrates Virus Visit Water Week Wolbachia Work base career cell type chemotherapy cytokine design enolase enzyme activity experience fatty acid binding protein fatty acid-binding proteins flash photolysis gamma-glutamylcysteine genetic manipulation health disparity immunopathology in vivo instrument interest international center medical schools melanoblast melanocyte member microcalorimetry migration minority health mutant neoplastic cell novel novel strategies parasitism performance site polymerization posters prevent professor programs protein structure function quinoline receptor relating to nervous system research study response simian T lymphotropic virus type II small hairpin RNA statistics success technical writing vaccine development vaccinology viral gene delivery

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中文摘要

翻译

描述（由申请人提供）：本申请是对国家少数民族健康和健康差异中心（NCMHD）和NIH Fogarty国际中心（FIC）针对波多黎各大学（UPR）少数民族健康和健康差异国际研究培训（MHIRT）传染病和分子生物学项目的RFA-MD-04-004的回应。这个竞争性的更新申请计划将包括10名研究实习生，其中75%将是本科生，其余的是博士和/或医学生或常驻研究员。UPR是高等教育的少数民族西班牙裔学生在美国的首要机构，是第一个在全国毕业的西班牙裔博士。主题是围绕国际卫生问题的广泛领域，重点是热带医学和寄生虫学的分子和免疫学方面，这是影响发展中国家人口和健康差距人口的健康问题。这包括穷人和处境不利者的疾病，如一种新出现的人类片形吸虫病、疟疾和艾滋病毒。此外，新血红蛋白的重要结构-功能研究，人类Hermansky Pudlak综合征中的黑素体生物发生，以及作为脊椎动物模型的棘皮动物的再生过程，在分子和发育生物学中完成了广泛的研究活动。欧洲和加拿大的业绩网站是那些目前或未来与波多黎各医学科学大学，里奥皮德拉斯和马亚圭斯校区，这是普遍定期审议系统的三个博士/研究校园的教师合作。这些国外站点包括位于西班牙萨拉曼卡、瓦伦西亚和格拉纳达的实验室;法国巴黎的CIMM;英国爱丁堡;加拿大蒙特利尔;以及澳大利亚悉尼。考虑对这些杰出的调查员进行10至12周或一个学期的培训。

英文摘要

DESCRIPTION (provided by applicant): This application is in response to RFA-MD-04-004 from the National Center on Minority Health and Health disparities (NCMHD) and the Fogarty International Center (FIC) of the NIH for a University of Puerto Rico (UPR) Minority Health and Health Disparities International Research Training (MHIRT) Program in Infectious Diseases and Molecular Biology. This competing renewal application program will include 10 research trainees, 75 % of which will be undergraduates, with the rest being doctoral and/or medical students or resident fellows. The UPR is the premier institution of higher learning for minority Hispanic students in the United States, and is first in the nation in graduating Hispanic Ph.Ds. The theme is around the broad area of international health problems focusing on molecular and immunological aspects of tropical medicine and parasitology, which are health problems that affect the populations of developing countries and of health disparities populations. This includes diseases of the poor and the disadvantaged as is human fascioliasis, which is a newly emerging disease, malaria, and HIV. Moreover, important structure-function studies of novel hemoglobins, melanosome biogenesis in human Hermansky Pudlak Syndrome, and regenerative processes in echinoderms as models for vertebrates, round out a broad range of research activities in molecular and developmental biology. The European and Canadian performance sites are of those currently or prospectively collaborating with faculty at the University of Puerto Rico Medical Sciences, Rio Piedras, and Mayaguez campuses which are the three doctoral/research campuses of the UPR system. These foreign sites include laboratories in Salamanca, Valencia, & Granada in Spain; INSERM in Paris, France; Edinburgh in the UK; Montreal, Canada; and Sydney, Australia. Training periods of 10-12 weeks or a semester with these outstanding investigators are contemplated.

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