通过混合连锁不平衡绘制波多黎各人 IBD 基因图谱-猫眼课题宝

通过混合连锁不平衡绘制波多黎各人 IBD 基因图谱

批准号：

7500236

负责人：

KENT D TAYLOR

金额：

$34.95万

依托单位：

CEDARS-SINAI MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

已结题

起止时间：

2002-09-30 至 2012-08-31

来源：

https://reporter.nih.gov/project-details/7500236

关键词：

13q Admixture African African American Algorithms Antibodies Area Behavior Bioinformatics Biological Markers Candidate Disease Gene Caucasians Caucasoid Race Characteristics Childhood Chromosome Mapping Classification Classification Scheme Clinical Clinical Data Clinical Management Collection Communication Complex Crohn&apos s disease DNA Data Data Collection Development Disease Disease Association Environment Environmental Risk Factor European Exposure to Future Genes Genetic Genetic Markers Genetic Research Genetic Variation Genetic screening method Genome Genotype Haplotypes Heterogeneity Human Genome Hygiene Infection Infectious Agent Inflammation Inflammatory Bowel Diseases Joints Lead Linkage Disequilibrium Location Maps Measurement Measures Medical center Methods Microbe Modeling Molecular National Institute of Diabetes and Digestive and Kidney Diseases Native Americans Onset of illness Pathogenesis Patients Phenotype Pilot Projects Population Population Study Predisposition Puerto Rican Puerto Rico Quality Control Questionnaires Recruitment Activity Research Design Research Personnel Resources Risk Role Sample Size Sampling Serum Severities Severity of illness Statistical Models Susceptibility Gene Symptoms Testing Time Ulcerative Colitis Universities Variant base clinical Diagnosis clinical phenotype clinically relevant cohort disorder subtype follow-up genetic analysis genetic variant genome wide association study lymphoblastoid cell line microorganism antigen programs response trait

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中文摘要

翻译

描述(由申请人提供)：本提案是为了响应RFA DK-06-504关于继续我们作为NIDDK炎症性肠病遗传学联合会(IBDGC)遗传研究中心(GRC)的角色而提交的。锡达斯-西奈医学中心将与波多黎各大学合作开展这一项目；UPR将负责招募IBD患者，CSMC将负责执行基因测试(基因分型)并分析结果，寻找人类基因组中包含增加IBD风险的基因的区域。波多黎各人口特别适合这种类型的研究；该人口是美洲原住民、非洲人和高加索人-欧洲人的复合体，这些人自哥伦布时代以来就在基因上混杂在一起。这种类型的遗传分析被称为“混合连锁不平衡作图”。

英文摘要

DESCRIPTION (provided by applicant): This proposal is submitted in response to the RFA DK-06-504 for continuing our role as a Genetic Research Center (GRC) of the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC). Cedars-Sinai Medical Center will collaborate with the University of Puerto Rico for this project; UPR will be responsible for recruiting IBD patients, and CSMC will be responsible for performing genetic tests (genotyping) and analyzing the results, looking for regions of the human genome that contain genes that increase the risk for IBD. The Puerto Rican population is particularly suited for this type of study; the population is a composite of Native-American, African, and Caucasian-European peoples that have mixed together genetically since the time of Columbus. This type of genetic analysis is termed "Mapping by Admixture Linkage Disequilibrium."

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会议论文

Mapping genes for IBD by admixture LD in Puerto Ricans

批准号：

7123085
项目类别：
资助金额：

$39.54万
财政年份：

2002
负责人：

KENT D TAYLOR
依托单位：

CEDARS-SINAI MEDICAL CENTER

Mapping the genes for IBD by admixture linkage disequilibrium in Puerto Ricans

批准号：

7337418
项目类别：
资助金额：

$37.06万
财政年份：

2002
负责人：

KENT D TAYLOR
依托单位：

CEDARS-SINAI MEDICAL CENTER

海外基金