Mechanisms of Oral Bacteria-Mediated Bone Resorption via Toll-Like Receptors

口腔细菌通过 Toll 样受体介导的骨吸收机制

• 批准号: 7622625
• 负责人: Hui Wu
• 金额: $ 5.7万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7622625
• 关键词: Actinobacillus actinomycetemcomitans; Alveolar Bone Loss; Bacteria; Bacterial Toxins; Bone Density; Bone Marrow; Bone Resorption; Bone remodeling; Calcium; Calcium Oscillations; Calcium Signaling; Cells; Coculture Techniques; Development; Disease; Equilibrium; Exhibits; Feasibility Studies; Foundations; Future; Gram-Negative Bacteria; Homeostasis; Human; Immune response; Immunologist; Infection; Inflammatory; Knockout Mice; Ligands; Localized; MAPK11 gene; MAPK14 gene; MEKs; Mammals; Manuscripts; Mediating; Metabolic Bone Diseases; Morphology; Mus; Numbers; Oral; Osteoblasts; Osteoclasts; Pathogenesis; Pathology; Pathway interactions; Periodontal Diseases; Periodontal Ligament; Periodontitis; Phenotype; Phosphorylation; Play; Process; Production; Protein Kinase C; Publications; Receptor Signaling; Reporting; Research Personnel; Research Project Grants; Resources; Role; Signal Pathway; Signal Transduction; Signaling Molecule; Stem cells; System; TLR4 gene; Testing; Tissues; Toll-like receptors; Virulence; Virulence Factors; Wild Type Mouse; alveolar bone; bone; career; cell type; cytokine; cytolethal distending toxin; extracellular; factor A; in vivo; macrophage; member; mutant; oral bacteria; oral pathogen; osteoclastogenesis; pathogen; receptor; response