Mucosal Immunology Core

粘膜免疫学核心

• 批准号: 7480739
• 负责人: Peter A Anton
• 金额: $ 6.05万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7480739
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Advertisements; Applications Grants; Area; Awareness; Biological Assay; Biopsy; Biostatistics Core; Blood; Blood Screening; Blood specimen; Books; Cells; Cervix Uteri; Clinical; Clinical Trials; Colon, Rectum; Communities; Consent Forms; Consult; Consultations; Core Facility; Databases; Development; Epithelium; Fostering; Funding; Gastroenterology; Gastrointestinal tract structure; Goals; Grant; HIV; HIV Infections; Human; Immune response; Immunologics; Immunology; Infection; Institutes; Knowledge; Laboratories; Link; Lymphocyte; Lymphoid Tissue; Minority; Mononuclear; Mucous Membrane; Operative Surgical Procedures; Pathogenesis; Patient Selection; Patients; Preparation; Process; Quality Control; RNA; Recruitment Activity; Registries; Research; Research Design; Research Ethics Committees; Research Personnel; Resources; Sampling; Seminal fluid; Services; Site; Small Intestines; Specimen; Stomach Diseases; Suspension substance; Suspensions; Techniques; Technology; Technology Transfer; Testing; Time; Tissue Procurements; Tissue Sample; Tissues; Tonsil; Training; United States National Institutes of Health; Vaccines; Validation; Viral Load result; Visit; Woman; chemokine; cohort; cytokine; gastrointestinal; innovation; interest; investigator training; microbicide; mucosal site; novel; rectum/anus; research study; response; sample collection; virology

The Mucosal Immunology Core Laboratory (MICL) was first proposed and funded in 1998 due to an emerging awareness that mucosal lymphoid tissues were critically important as a reservoir for HIV infection. To our knowledge, this was the first Core facility of its kind in CFAR and continues to be a unique resource nationally. Interested researchers had little access to freshly acquired tissue and there were no validated assays for quantifying tissue HIV viral burden as well as other relevant mucosal immunologic and virologic markers. Since the start of the most recent CFAR renewal 4.5 years ago, the MICL has collected over 8000 mucosal tissue biopsies for study from 362 subjects. An additional 407 MICL encounters include 235 subject visits for screening, blood or semen donation without biopsies and 172 tissue specimens received from collaborators for assays or tissue specimens received from the Tissue Procurement Core Laboratory (TPCL). Also the MICL has supported 21 researchers (8 non-UCLA), 21 grant applications (16 funded), and during the past 2 years the MICL has developed a Clinical Trial Registry of 317 potential subjects for proactive recruitment as needed. This resource in unmatched anywhere and is a very unique CFAR resource for HIV investigators.

粘液免疫学核心实验室（MICL）于1998年首次提出并获得资助， 人们逐渐认识到粘膜淋巴组织作为HIV感染的储存库至关重要。 据我们所知，这是CFAR的第一个此类核心设施，并将继续成为一种独特的资源 全国范围内。感兴趣的研究人员几乎没有机会获得新鲜获得的组织， 用于定量组织HIV病毒负荷以及其他相关粘膜免疫学和病毒学的测定 标记。自从4.5年前开始最近一次CFAR更新以来，MICL已经收集了8000多个 来自362名受试者的用于研究的粘膜组织活检。另外407例MICL病例包括235例受试者 筛查访视，无活检的血液或精液捐献，从 从组织采购核心实验室接收的试验或组织标本的合作者 （TPCL）。此外，MICL还支持了21名研究人员（8名非加州大学洛杉矶分校），21项赠款申请（16项资助）， 在过去的2年中，MICL已经开发了一个317名潜在受试者的临床试验注册表， 根据需要积极招聘。这种资源在任何地方都是无与伦比的，是一个非常独特的CFAR 艾滋病调查人员的资源。