Shock Center for Aging Research at The Jackson Laborato*

描述（由申请人提供）：为了鉴定基因并探索调节人类衰老和对年龄相关疾病易感性的分子途径，充分表征和遗传定义的小鼠提供了一种选择模型系统。杰克逊实验室拥有丰富的近交系和突变品系的小鼠，在小鼠饲养方面的专业知识，以及在小鼠生物学方面的多样性，因为它适用于衰老。在杰克逊实验室建立一个内森休克卓越中心的生物学老化将支持一个已经显着水平的年龄相关的研究在这里，并通过一个研究开发核心，吸引既建立调查人员和新招募的探索自己的研究计划与有关衰老的问题的关系。此外，由于杰克逊实验室是一个国际资源的信息和独特的小鼠品系，一个内森休克中心在这里的贡献将在全国范围内发挥杠杆作用。来自各个中心成员研究群体的小鼠将在分散的动物核心中老化，这将向其他中心成员和外部科学家开放与衰老相关的大量遗传资源。Phenome Core将提供一种全新的预测性数量性状分析能力，以加速衰老生物学的遗传分析，通过表征一组常用的遗传多样性小鼠品系的衰老参数，并在公开的小鼠表型数据库中使用详细的基因组序列和映射数据来管理数据。该中心还将支持增强体内成像，生理测量和显微镜的能力，以通过表型核心评估衰老的表型。计算核心将为统计遗传学分析和工作流程管理工具提供支持。总之，杰克逊实验室的内森休克中心将为国际社会提供更多的资源，并更好地了解衰老及其相关疾病的分子机制。

DESCRIPTION (provided by applicant): To identify genes and explore molecular pathways that regulate aging and susceptibility to age-related disorders in humans, well-characterized and genetically defined mice offer a choice model system. The Jackson Laboratory has a wealth of inbred and mutant strains of mice, expertise in mouse husbandry, and diversity of expertise in the biology of the mouse as it applies to aging. Establishing a Nathan Shock Center for Excellence in the Biology of Aging at The Jackson Laboratory will support an already significant level of age-related research here and, through a Research Development Core, attract both established investigators and new recruits to explore the relationship of their own research programs with questions pertinent to aging. Moreover, because The Jackson Laboratory is an international resource for information and unique strains of mice, the contribution of a Nathan Shock Center here will be leveraged nationally. Mice from individual Center members' research colonies will be aged in a dispersed Animal Core, that will open an enormous variety of genetic resources relevant to aging to other Center members and external scientists. The Phenome Core will offer an entirely new capability for predictive quantitative trait analysis to accelerate genetic analysis of the biology of aging, by characterizing parameters of aging for a set of commonly used, genetically diverse strains of mice and curating the data with detailed genomic sequence and mapping data in the publicly available Mouse Phenome Database. The Center will also support enhanced capabilities for invivo imaging, physiological measurements, and microscopy to evaluate phenotypes of aging through a Phenotyping Core. The Computing Core will provide support for statistical genetics analysis and workflow management tools. In sum, the Nathan Shock Center at The Jackson Laboratory will lead to enhanced resources for the international community and better understanding of the molecular mechanisms at work in aging and its associated disorders.