CORE--CHEMISTRY AND PET IMAGING

化学和PET成像核心将利用加州大学洛杉矶分校PET计划的两个技术中心的资源：分子成像探针生产和PET成像仪器。分子成像探针生产技术中心负责本次申报项目中所有放射性药物的生产。用O-15、N-13、C-11和F-18标记的广泛的产品被常规地合成、纯化并根据各种不同的方案提供给各种研究者。该技术中心不断探索新的放射性同位素生产技术，新的前体合成和新的放射性标记试剂。它的活动还侧重于改进现有方法的放射化学产率、新的自动放射合成模块和减少个人辐射照射的方法。对于本计划项目赠款，技术中心将提供[18F]FDG、[18F]FDDNP和[18F]MPPF。PET成像仪器核心提供并支持所有计划研究者使用的成像仪器。确保所有仪器设备的维护和良好的运行状态，并执行定期的日/月质量控制。 它还教育研究人员了解仪器的能力和局限性，并协助他们规划和执行实验。它确保测量的定量准确性（在适用的情况下），并与计算和建模技术中心（图像分析核心：Sung Cheng Huang，核心负责人）合作，指导研究人员进行数据解释。此外，它还确保了适当的数据存档和存储，以及研究人员遵守所有地方、州和联邦管理分子生物学的法规。 动物和人类的成像研究。该核心将提供和维护必要的断层扫描和辅助设备和资源，以执行本资助申请中提出的人体PET和microPET扫描;执行定期质量控制;实施和维护所有操作的详细日志;协调，安排并优化所有断层扫描仪和辅助设备的使用（即伽马计数器）;维护和升级断层摄影设备和计算机系统，以进行数据收集、图像重建和传输;协助 研究人员计划和执行成像系统研究，包括遵守所有地方、州和联邦法规，以进行动物和人类生物成像研究。

The Chemistry and PET Imaging Core will use the resources of two technical centers in the UCLA PET program: the Molecular Imaging Probe Production and the PET Imaging Instrumentation. The Molecular Imaging Probe Production Technical Center is responsible for the production of all the radiopharmaceuticals for the project included in this application. A wide range of products labeled with O-15, N-13, C-11 and F-18 are routinely synthesized, purified and provided to various investigators under a variety of different protocols. This Technical Center continually explores new radioisotope production techniques, new precursor syntheses and new radiolabeled reagents. It also focuses its activities in improvement of the radiochemical yields of established methods, new automated radiosynthesis modules and ways to reduce personal radiation exposures. For this Program Project grant the Technical Center will provide [18F]FDG, [18F]FDDNP and [18F]MPPF. The PET Imaging Instrumentation Core provides and supports the imaging instruments used by all Program investigators. It ensures that all instruments are maintained and kept in good running order and performs the periodic daily/monthly quality contol. It also educates investigators about the capabilities and limitations of the instruments and assists them in planning and executing their experiments. It ensures the quantitative accuracy of their measurements (wherever applicable) and in collaboration with the Computation and Modeling Tech Center (Image Analysis Core: Sung Cheng Huang, Core Leader) guides investigators in their data interpretation. In addition it ensures the proper data archival and storage, as well as compliance of investigators with all local, state and federal regulations governing molecular imaging research with animals and humans. This Core will provide and maintain the necessary tomographic and ancillary equipment and resources to perform human PET and microPET scans proposed in this grant application; perform periodic quality controls; implement and maintain detailed logs of all the operations; coordinate, schedule and optimize the use of all the tomographs and ancillary equipment (i.e. gamma counters) necessary in this application with the cyclotron production of short-lived molecular imaging probes; maintain and upgrade tomographic equipment and computer systems for data collection, image reconstruction and transfer; assist investigators in planning and performing studies with the imaging systems, including compliance with all local, state and federal regulations to conduct biological imaging research with animals and humans.