Tadpole Assays for the Molecular Assessment of Cancer

用于癌症分子评估的蝌蚪试验“ 生物学家早就知道，癌细胞有时会通过释放某些物质来宣布它们的存在。 分子进入血液。最近，许多人开始相信一些癌症可能是 通常存在于血液中的一组分子的模式可以通过“信号”检测到，但在 对于某些癌症，出现的量高于或低于正常水平。最近，我们学会了如何制作 新型分子，我们称之为“蝌蚪”。我们已经证明，我们可以使用它们来 检测和计数少量的分子。这些化验方法相对简单和相对 便宜，而且它们应该适用于这两种癌症检测。在接下来的三年里， 我们寻求资金来开发和“强化”这些分析，以使它们可以在临床上进行测试。 癌症诊断。

Tadpole assays for the molecular assessment of cancer" Biologists have long known that cancer cells sometimes announce their presence by sheddingcertain molecules into the blood. More recently, many have come to believe that some cancers might be detectable by "signatures", patterns of sets of molecules, perhaps normally present in the blood, but, in for certain cancers, present in higher or lower amounts than normal. Recently, we learned to make new kinds of molecules, which we call "tadpoles". We have demonstrated that we can use them to detect and count small numbers of molecules. These assays are relatively simple and relatively inexpensive, and they should be applicable to both kinds of cancer detection. During the next 3 years, we seek funding to develop and "harden" these assays to the point that they can be tested inclinical cancer diagnosis.