UT Southwestern O'Brien Kidney Research Core Center

总体描述(由申请人提供)： 这是在达拉斯的德克萨斯大学西南医学中心建立乔治·M·奥布莱恩肾脏研究核心中心的新申请。主任是内科和儿科教授、肾病科主任Peter Igarashi博士。该中心的总体目标是促进基础科学家和临床研究人员之间的双向互动，这将增强我们对肾脏发育和病理生理学的了解，并导致更有效地治疗肾脏疾病及其并发症。这一目标将通过创建新的肾脏疾病动物模型和开发核心设施来实现，这些设施将使进行基础研究的内科科学家能够更容易地将他们的发现转化为人类。相反，研究肾脏疾病患者的临床研究人员将识别分子和遗传异常，然后可以对这些异常进行研究，以得出对疾病发病机制和治疗的新见解。为了实现这些目标，该中心将支持五个生物医学研究中心，一个试点和可行性计划，以及一个教育充实计划。生物医学研究的核心是：1)动物模型，2)生理学，3)细胞生物学和病理学，4)分子遗传学，5)临床/翻译。这些核心将支持德克萨斯大学西南部、德克萨斯州北部地区、全国和国际上正在进行的与肾脏相关的研究。该研究基地由41名外部资助的研究人员组成，他们在肾脏生理和细胞生物学、损伤和炎症、发育生物学和分子遗传学以及肾囊性疾病等领域进行基础研究。临床/翻译研究的领域包括急性和慢性肾脏疾病、肾脏和心血管疾病以及电解质和矿物质代谢。该中心将位于肾病科新装修的15,000平方英尺空间内，并将利用现有的人类遗传学、转基因技术和分子病理学的核心设施。试点和可行性计划将为新进入该领域的研究人员每年提供两笔赠款。教育充实计划将包括一次研究研讨会、年度研讨会、培训补助金和一个新系提供的课程。临床科学奖。通过加强现有的合作和吸引外部研究人员，该中心将促进新的多学科方法来了解肾脏疾病的原因和治疗。

DESCRIPTION, OVERALL (provided by applicant): This is a new application for the establishment of a George M. O'Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center at Dallas. The Director is Dr. Peter Igarashi, Professor of Internal Medicine and Pediatrics, and Chief of the Division of Nephrology. The overall goal of the Center is to promote bidirectional interactions between basic scientists and clinical researchers that will enhance our understanding of kidney development and pathophysiology and result in more effective treatments of kidney diseases and their complications. This goal will be achieved through the creation of new animal models of kidney diseases and the development of core facilities that will enable physician-scientists who are conducting basic research to more easily translate their findings to humans. Conversely, clinical investigators who are studying patients with renal diseases will identify molecular and genetic abnormalities that can then be studied to derive new insights into disease pathogenesis and treatment. To achieve these goals, the Center will support five Biomedical Research Cores, a Pilot & Feasibility Program, and an Educational Enrichment Program. The Biomedical Research Cores are: 1) Animal Models, 2) Physiology, 3) Cell Biology & Pathology, 4) Molecular Genetics, and 5) Clinical/Translational. The Cores will support ongoing, kidney- related research conducted at UT Southwestern, the North Texas region, nationally, and internationally. The research base consists of 41 externally funded investigators who are conducting basic research in the areas of kidney physiology & cell biology, injury & inflammation, developmental biology & molecular genetics, and renal cystic diseases. Clinical/translational research is conducted in the areas of acute & chronic kidney disease, kidney & cardiovascular disease, and electrolyte & mineral metabolism. The Center will be located in 15,000 sq ft of newly renovated space in the nephrology division and will utilize existing core facilities in human genetics, transgenic technologies, and molecular pathology. The Pilot & Feasibility Program will support two grants per year for investigators who are new to the field. The Educational Enrichment Program will include a research seminar, annual symposium, training grants, and courses offered by a new Dept. of Clinical Sciences. By strengthening existing collaborations and attracting outside investigators, the Center will promote new multidisciplinary approaches to understanding the causes and treatment of renal diseases.