Pilot Project Program

试点项目计划

• 批准号: 7239321
• 负责人: DOUGLAS S DARLING
• 金额: $ 14.8万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7239321
• 关键词: Accounting; Award; Binding; Biology; Budgets; Committee Members; Complementary DNA; Confidentiality; Conflict of Interest; Core Facility; Data; Dental Hygiene; Development; Direct Costs; Electronics; Endodontics; Environmental Health; Eukaryotic Cell; Family; Funding; Genes; Genetic; Genetic Transcription; Genomics; Goals; Grant Review Process; Guidelines; Incentives; Laboratories; Letters; Molecular Mechanisms of Action; Molecular Medicine; Numbers; Oral; Outcome; Periodontic specialty; Pilot Projects; Private Sector; Procedures; Progress Reports; Published Comment; Recommendation; Records; Regulation; Request for Proposals; Research; Research Personnel; Research Project Grants; Role; Sampling; School Dentistry; Score; Services; Writing; Zinc Fingers; day; design; enhancer binding protein; experience; flyer; homeodomain; innovation; interest; member; professor; programs; tool; transcription factor

Overview CEGIB will support a Pilot Project Program designed to encourage new and innovative research approaches with emphasis given to creative new lines of research in environmental genomics and integrative biology. The Program will support short-term research projects to enable researchers to collect the data necessary to obtain funding through governmental and private sector agencies. The primary goal for this program will be to develop innovative ideas of importance to environmental health sciences. Emphasis will be given to support of young investigators as a tool to launch their research programs and to increase collaborative opportunities with established environmental health investigators. \ Dr. Douglas S. Darling, Associate Professor in the Department of Periodontics, Endodontics and Dental Hygiene in the School of Dentistry will direct the Center Pilot Project. Dr. Darling is an experienced leader in internal grant review processes, having provided oversight for the Center for Genetics and Molecular Medicine's pilot project efforts for the past three years. He is respected for the high degree of integrity and confidentiality with which he manages award determinations. He will provide 5% effort to the oversight of the Pilot Project Program and service as a member of the Internal Advisory Board. Dr. Darling's research interests are in the regulation of gene transcription in eukaryotic cells. His laboratory investigates the molecular mechanism of action of the zfh family of transcription factors. They have isolated cDNA and genomic clones of the Zinc Finger Homeodomain Enhancer-binding Protein (Zfhep) gene and current projects are investigating the role of molecular interactions that underlie Zfhep and related genes in early development. The Pilot Project Program procedures will function under the following guidelines: ¿ A Request for Proposals announcement will be distributed by the CEGIB Administrative Core to UofL investigators and laboratories via electronic and hardcopy flyer distribution and campus bulletin board postings at least 60 days prior to the date of submission. A sample Request for Proposals is included with this application. ¿ Submitted proposals will be collected by the Administrative Core and forwarded to the Pilot Project Committee. The Pilot Project Committee will be chaired by Dr. Douglas Darling and will consist of four ad hoc members selected by the Center Director for their expertise and representation of all Research Cores. Committee members will be screened for conflict of interest that might arise from one or more of the submitted proposals. ¿ The Pilot Project Committee will forward the submissions to experts in their appropriate field for external scientific merit review. The Committee will conduct an NIH-style review, including consideration of the external reviews and scores. This information will be used to make recommendations to the Center Director concerning funding. ¿ As directed by the CEGIB Director, the Administrative Core staff will prepare a Letter of Award and will establish accounting access to the awarded funds for the recipients. ¿ Projects will be funded for one year. The number and amounts awarded each year may vary with the number of meritorious proposals received and the availability of funds. At least 20% and up to the maximum allowed 25% of the direct cost budget for each year will be designated for the Pilot Project Program. Pilot Project recipients will be encouraged to use the CEGIB Facility Cores where they will be afforded the same incentives as CEGIB members. Each Pilot Project recipient will provide a written progress report on his or her projects and will give an oral presentation to CEGIB members at the annual meeting of the External Advisory Board. ¿ Records of the Pilot Project Program will be maintained by the CEGIB Administrative Core, including minutes of the Pilot Project Committee meetings, reviewer comments, accounting records, written progress reports, and copies of all submitted proposals and their outcomes.

概述 CEGIB将支持旨在鼓励新的和创新的研究方法的试点项目计划 重点放在环境基因组学和综合生物学的创新研究领域。的 该计划将支持短期研究项目，使研究人员能够收集必要的数据， 通过政府和私营部门机构提供资金。该计划的主要目标是 发展对环境健康科学具有重要意义的创新思想。将重点支持 年轻的研究人员作为一种工具，启动他们的研究计划，并增加合作的机会， 设立环境卫生调查员。 \ 博士道格拉斯S. Darling，牙周病学，牙髓病学和牙科系副教授 牙科学院的卫生将指导中心试点项目。达林博士是一位经验丰富的领导者， 内部拨款审查程序，为遗传学和分子生物学中心提供监督 医药试点项目努力了三年。他因高度的正直而受到尊敬， 他管理裁决的保密性。他将提供5%的努力，以监督 试点项目计划和服务作为内部咨询委员会的成员。达林博士的研究 兴趣在于真核细胞中基因转录的调节。他的实验室研究了 转录因子ZFH家族的分子作用机制。他们已经分离出cDNA， 锌指同源结构域增强子结合蛋白（Zfhep）基因的基因组克隆和当前项目 正在研究Zfhep和相关基因在早期乳腺癌中的分子相互作用的作用， 发展 试点项目程序将根据以下指导原则运行： CEGIB行政核心将向以下人员分发征求建议书公告： UofL研究人员和实验室通过电子和硬拷贝传单分发和校园 在提交日期前至少60天在公告板上张贴。一个示例请求 建议书包含在此应用程序中。 提交的提案将由行政核心收集并转交给试点 项目委员会。试点项目委员会将由道格拉斯达林博士担任主席， 由中心主任根据其专业知识挑选的四名临时成员组成， 代表所有研究核心。委员会成员将被筛选的冲突， 一个或多个提交的提案可能引起的兴趣。 试点项目委员会将把提交的材料转交给相关领域的专家， 外部科学价值审查。委员会将进行NIH式的审查，包括 考虑外部评论和评分。这些信息将用于 向中心主任提出有关资金的建议。 根据CEGIB主任的指示，行政核心工作人员将准备一封获奖信。 并将为接受者建立对所授予资金的会计访问。 这些项目将获得一年的资助。每年的数量和金额可能会有所不同 我们会视乎所收到的建议书的数目和可动用的资金而定。至少20% 每年直接费用预算的最高允许额为25%， 试点项目方案。鼓励试点项目的受援国使用CEGIB 设施核心，他们将获得与CEGIB成员相同的奖励。 每个试点项目的接受者将提供一份关于其项目的书面进度报告，并将 在外部咨询委员会年度会议上向CEGIB成员作口头报告 纸板. 试点项目计划的记录将由CEGIB行政核心保存， 包括试点项目委员会会议记录、评审意见、会计 记录、书面进度报告以及所有提交的提案及其结果的副本。