Pilot Project Program

概述 CEGIB将支持一个旨在鼓励新的和创新的研究方法的试点项目计划 重点是环境基因组学和综合生物学方面的创造性研究新路线。这个 该计划将支持短期研究项目，使研究人员能够收集必要的数据，以获得 通过政府和私营部门机构提供资金。该计划的主要目标将是 发展对环境健康科学具有重要意义的创新理念。将重点支持 将青年研究人员作为启动其研究计划和增加与 有经验的环境健康调查人员。 \ 道格拉斯·S·达林博士，牙周学、牙髓和牙学系副教授 牙科学校的卫生将指导该中心的试点项目。达林博士是一位经验丰富的领导者 内部拨款审查程序，为遗传学和分子中心提供监督 医学的试点项目在过去三年中所做的努力。他因高度的正直和 他管理裁决的机密性。他将提供5%的努力来监督 作为内部咨询委员会成员的试点项目计划和服务。达林博士的研究 人们感兴趣的是真核细胞中基因转录的调控。他的实验室调查 转录因子ZFH家族作用的分子机制。他们已经分离出了cdna和 锌指同源域增强子结合蛋白(Zfhep)基因的基因组克隆及最新计划 正在研究Zfhep和相关基因背后的分子相互作用在早期 发展。 试点项目方案程序将在以下指导方针下运作： ·CEGIB行政核心将发布征求建议书公告，以 UofL调查人员和实验室通过电子和硬拷贝传单分发和校园 在提交日期前至少60天张贴公告栏。以下是一个示例请求 建议书包含在本申请中。 提交的建议书将由行政核心收集并转发给试点 项目委员会。试点项目委员会将由道格拉斯·达林博士担任主席，并将 由四名特别成员组成，由中心主任根据其专业知识和 代表所有研究核心。委员会成员将被筛查是否存在冲突 提交的一份或多份建议书可能产生的利益。 试点项目委员会将把提交的材料转交给其相应领域的专家，以便 外部科学功绩审查。该委员会将进行NIH式的审查，包括 考虑外部评审和分数。这些信息将被用来制作 就资金问题向中心主任提出建议。 ？根据CEGIB主任的指示，行政核心工作人员将准备一份中标信 并将为获奖者建立获得奖励资金的会计通道。 ？项目将获得为期一年的资助。每年的奖励数目和金额可能会有所不同。 与收到的有功提案的数量和资金的可获得性有关。至少20% 并将指定每年直接成本预算的最高允许比例为25% 用于试点项目计划。将鼓励试点项目获得者使用CEGIB 设施核心，他们将获得与CEGIB成员相同的激励措施。 每个试点项目接受者将提供一份关于其项目的书面进度报告，并将 在外部咨询年度会议上向CEGIB成员作口头介绍 冲浪板。 ？试点项目计划的记录将由CEGIB管理核心维护， 包括试点项目委员会的会议记录、审查员意见、会计 记录、书面进度报告以及所有提交的提案及其结果的副本。

Overview CEGIB will support a Pilot Project Program designed to encourage new and innovative research approaches with emphasis given to creative new lines of research in environmental genomics and integrative biology. The Program will support short-term research projects to enable researchers to collect the data necessary to obtain funding through governmental and private sector agencies. The primary goal for this program will be to develop innovative ideas of importance to environmental health sciences. Emphasis will be given to support of young investigators as a tool to launch their research programs and to increase collaborative opportunities with established environmental health investigators. \ Dr. Douglas S. Darling, Associate Professor in the Department of Periodontics, Endodontics and Dental Hygiene in the School of Dentistry will direct the Center Pilot Project. Dr. Darling is an experienced leader in internal grant review processes, having provided oversight for the Center for Genetics and Molecular Medicine's pilot project efforts for the past three years. He is respected for the high degree of integrity and confidentiality with which he manages award determinations. He will provide 5% effort to the oversight of the Pilot Project Program and service as a member of the Internal Advisory Board. Dr. Darling's research interests are in the regulation of gene transcription in eukaryotic cells. His laboratory investigates the molecular mechanism of action of the zfh family of transcription factors. They have isolated cDNA and genomic clones of the Zinc Finger Homeodomain Enhancer-binding Protein (Zfhep) gene and current projects are investigating the role of molecular interactions that underlie Zfhep and related genes in early development. The Pilot Project Program procedures will function under the following guidelines: ¿ A Request for Proposals announcement will be distributed by the CEGIB Administrative Core to UofL investigators and laboratories via electronic and hardcopy flyer distribution and campus bulletin board postings at least 60 days prior to the date of submission. A sample Request for Proposals is included with this application. ¿ Submitted proposals will be collected by the Administrative Core and forwarded to the Pilot Project Committee. The Pilot Project Committee will be chaired by Dr. Douglas Darling and will consist of four ad hoc members selected by the Center Director for their expertise and representation of all Research Cores. Committee members will be screened for conflict of interest that might arise from one or more of the submitted proposals. ¿ The Pilot Project Committee will forward the submissions to experts in their appropriate field for external scientific merit review. The Committee will conduct an NIH-style review, including consideration of the external reviews and scores. This information will be used to make recommendations to the Center Director concerning funding. ¿ As directed by the CEGIB Director, the Administrative Core staff will prepare a Letter of Award and will establish accounting access to the awarded funds for the recipients. ¿ Projects will be funded for one year. The number and amounts awarded each year may vary with the number of meritorious proposals received and the availability of funds. At least 20% and up to the maximum allowed 25% of the direct cost budget for each year will be designated for the Pilot Project Program. Pilot Project recipients will be encouraged to use the CEGIB Facility Cores where they will be afforded the same incentives as CEGIB members. Each Pilot Project recipient will provide a written progress report on his or her projects and will give an oral presentation to CEGIB members at the annual meeting of the External Advisory Board. ¿ Records of the Pilot Project Program will be maintained by the CEGIB Administrative Core, including minutes of the Pilot Project Committee meetings, reviewer comments, accounting records, written progress reports, and copies of all submitted proposals and their outcomes.