Lung Epithelium in Development and Disease

肺上皮的发育和疾病

• 批准号: 7535435
• 负责人: JOHN M SHANNON
• 金额: $ 2.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7535435
• 关键词: Academy; Acute; Air; Alveolus; Apoptosis; Area; Back; Biology; Blood; Breathing; Carbon Dioxide; Cell Line; Cell physiology; Cells; Cellular biology; Climate; Cytoprotection; Development; Developmental Cell Biology; Disease; Epithelial; Epithelial Cells; Epithelium; Exhalation; Functional disorder; Funding; Future; Gases; Goals; Homeostasis; Immune response; Individual; Injury; Learning; Lung; Lung diseases; Mediating; Mesenchymal; Molecular; Morphogenesis; Mucosal Immunity; Organ; Oxygen; Participant; Persons; Play; Process; Regulation; Request for Applications; Research; Research Personnel; Respiratory physiology; Rivers; Role; Stem cells; Vermont; abstracting; concept; design; interest; lung development; lung injury; microorganism; novel strategies; particle; planetary Atmosphere; pollutant; repaired; surfactant; symposium

DESCRIPTION (Provided by applicant): This application requests partial funding of a FASEB Summer Research Conference entitled Lung Epithelium in Development and Disease, to be held August 3 - 8, 2008 at The Vermont Academy, Saxtons River, VT. Attendance is limited to 160 persons to create a climate conducive to interaction among the participants. The overall objective of this conference is to provide a forum for presenting new and cutting-edge information regarding the molecular mechanisms regulating the cell and developmental biology of the normal lung epithelium, and how these may be altered in lung disease. The specific topics to be covered in this conference include: (1) Molecular regulation of lung morphogenesis and cell fate commitment; (2) New concepts in airway epithelial cell function in the normal and diseased lung; (3) Lung epithelial stem cells, epithelial-mesenchymal transition, and their involvement in lung disease; (4) Regulation of surfactant homeostasis and mechanisms involved in its pathophysiology; (5) Molecular mechanisms underlying specific rare lung diseases; (6) Lung epithelial cytoprotection and programmed cell death, and the role these processes play in lung injury; (7) Molecular mechanisms mediating acute lung epithelial injury and its repair; and (8) Role of mucosal immunity in modulating the innate immune response within airways and the alveolus. We believe that this meeting is unique and highly important because it will bring together recognized experts in areas of intense interest in lung epithelial biology in a venue designed to both disseminate new information and to promote the interaction of established and junior investigators. We believe that this meeting will provide a framework for novel approaches and directions for future research on lung epithelial cell biology. The lung is the critical organ where inhaled oxygen is transferred to the blood and where exhaled carbon dioxide is released back into the atmosphere. The airways and gas-exchanging sacs of the lung are lined by cells that make up the lung epithelium. These cells not only act in conducting air and gas exchange, but also contribute to the individual's defense against inhaled particles, pollutants, and microorganisms. The mechanisms that regulate the normal development of the lung epithelium are only partially understood. Furthermore, much remains to be learned about how the lung epithelium responds to injury and disease to restore normal function. This conference will bring together recognized experts studying many facets of lung function who will share and discuss their recent important findings, with the ultimate goal of devising better strategies for the understanding and treatment of lung disease. (End of Abstract)

描述（由申请人提供）： 本申请要求部分资金的FASEB夏季研究会议题为肺上皮细胞在发展和疾病，将于2008年8月3日至8日在佛蒙特州学院，萨克顿河，佛蒙特州。出席人数限制为160人，以创造有利于与会者之间互动的气氛。本次会议的总体目标是提供一个论坛，介绍有关调节正常肺上皮细胞和发育生物学的分子机制的新的和前沿的信息，以及如何在肺部疾病中改变这些信息。本次会议的具体议题包括：（1）肺形态发生和细胞命运的分子调控;（2）正常和病变肺中气道上皮细胞功能的新概念;（3）肺上皮干细胞、上皮-间质转化及其在肺疾病中的作用;（4）肺表面活性物质稳态的调节及其病理生理机制;（5）肺表面活性物质在肺疾病中的作用。（5）特定罕见肺部疾病的分子机制;（6）肺上皮细胞保护和程序性细胞死亡，以及这些过程在肺损伤中的作用;（7）介导急性肺上皮损伤及其修复的分子机制;（8）粘膜免疫在调节气道和肺泡内先天免疫应答中的作用。我们认为，这次会议是独特的，非常重要的，因为它将汇集在肺上皮生物学领域的公认专家，在一个旨在传播新信息和促进既定和初级研究人员互动的场所。我们相信，这次会议将提供一个新的方法和方向，为未来的研究肺上皮细胞生物学的框架。肺是将吸入的氧气转移到血液中以及将呼出的二氧化碳释放回大气中的关键器官。肺的气道和气体交换囊由构成肺上皮的细胞排列。这些细胞不仅进行空气和气体交换，还有助于个人对吸入颗粒，污染物和微生物的防御。调节肺上皮正常发育的机制仅部分了解。此外，关于肺上皮如何对损伤和疾病作出反应以恢复正常功能，仍有许多有待了解。本次会议将汇集研究肺功能许多方面的公认专家，他们将分享和讨论他们最近的重要发现，最终目标是为理解和治疗肺部疾病制定更好的策略。(End摘要）