2008 Barriers of the CNS Gordon Research Conference

2008 CNS 戈登研究会议的障碍

• 批准号: 7476625
• 负责人: THOMAS Paul DAVIS
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476625
• 关键词: Address; Alzheimer' s Disease; Area; Basic Science; Blood; Blood - brain barrier anatomy; Brain; Central Nervous System Diseases; Clinical; Communities; Disease; Future; Goals; Health; Image; Inflammation; International; Knowledge; Maps; Neuraxis; New Hampshire; Numbers; Participant; Patients; Pharmaceutical Preparations; Play; Public Health; Regulation; Request for Proposals; Research; Research Personnel; Retinal; Role; Schools; Spinal Neoplasms; Stroke; Structure of choroid plexus; Therapeutic; Tight Junctions; Work; day; neurovascular unit; programs; symposium

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting to be held on Barriers of the Central Nervous System (CNS) in Tilton, New Hampshire on June 22 to 27, 2008. The broad and long term goal of this conference is to increase our understanding of the fundamental mechanisms associated with the blood brain barrier (BBB)/neurovascular unit (NVU) in health and disease. One of the primary goals of this meeting is to understand why the BBB excludes important therapeutics from entering the brain of people afflicted with diseases of the CNS. The issue of CNS disease states and the role the BBB/NVU plays in these disease states is the central theme of our meeting. The Gordon Research Conference (GRC) on Barriers of the CNS is unique because it brings together (equally) both clinical and basic science researches in a format where full and honest exchange occurs on subjects important to the patient. It is to our mutual benefit that we work together to solve the long term problem associated with an inability to treat CNS disease states because of our paucity of knowledge about the BBB/NVU. The Specific Aims of this meeting will be to convene 45 speakers that present critical areas of both basic and clinical disease research with a total of 150 participants for a five day conference in the isolated and private setting of Tilton School, Tilton, New Hampshire. The program will have two keynote addresses and eight sessions that broadly address current issues in BBB Tight Junctions and Barrier Regulation, BBB Transporters and Barrier Functions, Choroid plexus/Blood-CSF Barrier in health and disease, BBB/NVU imaging, retinal-, spinal-, and tumor barriers, BBB/NVU in stroke, BBB/NVU in Alzheimer's disease, and the BBB/NVU in inflammation. The significance of this application is that the GRC on Barriers of the CNS is one half of the total number of conferences offered in the area of Barriers of the CNS. Only one other conference is offered and it is offered in alternate years to the GRC. This GRC is our only conference every two years. This GRC conference propels research in the international community of BBB/NVU researchers. The health relatedness of this application is clear. Discussions will define strategies to treat CNS disease states with drugs. Discussions at GRC will map the future for defining how to understand CNS disease states and the BBB/NVU and discuss why many CNS therapeutics have been unsuccessful to date. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is clear. Discussions will define strategies to treat CNS disease states with drugs. Discussions at GRC will map the future for defining how to understand CNS disease states and the BBB/NVU and discuss why many CNS therapeutics have been unsuccessful to date.

描述（由申请人提供）：本提案要求对将于2008年6月22日至27日在新罕布什尔州蒂尔顿举行的关于中枢神经系统（CNS）障碍的国际会议提供部分支持。本次会议的广泛和长期目标是增加我们对健康和疾病中与血脑屏障（BBB）/神经血管单位（NVU）相关的基本机制的理解。本次会议的主要目标之一是了解为什么BBB排除重要的治疗药物进入患有CNS疾病的人的大脑。CNS疾病状态的问题和BBB/NVU在这些疾病状态中的作用是我们会议的中心主题。戈登研究会议（GRC）的中枢神经系统的障碍是独一无二的，因为它汇集了（平等）临床和基础科学研究的格式，其中充分和诚实的交流发生在重要的主题，病人。由于我们对BBB/NVU缺乏了解，我们共同努力解决与无法治疗CNS疾病状态相关的长期问题，这对我们双方都有利。本次会议的具体目标是召集45位演讲者，介绍基础和临床疾病研究的关键领域，共有150名与会者参加为期五天的会议，地点是新罕布什尔州蒂尔顿的蒂尔顿学校。该计划将有两个主题演讲和八个会议，广泛解决当前的问题，BBB紧密连接和屏障调节，BBB转运蛋白和屏障功能，健康和疾病中的脉络丛/血液-CSF屏障，BBB/NVU成像，视网膜，脊髓和肿瘤屏障，BBB/NVU中风，BBB/NVU阿尔茨海默病和炎症中的BBB/NVU。这一应用的重要性在于，关于中枢神经系统障碍的GRC是中枢神经系统障碍领域提供的会议总数的一半。只有一个其他会议是提供，它是提供在隔年的GRC。这个GRC是我们每两年唯一的会议。这个GRC会议推动了BBB/NVU研究人员国际社会的研究。该应用程序的健康相关性是明确的。讨论将确定用药物治疗CNS疾病状态的策略。GRC的讨论将描绘未来如何理解CNS疾病状态和BBB/NVU，并讨论为什么迄今为止许多CNS治疗方法都不成功。公共卫生相关性：本申请的健康相关性是明确的。讨论将确定用药物治疗CNS疾病状态的策略。GRC的讨论将描绘未来如何理解CNS疾病状态和BBB/NVU，并讨论为什么迄今为止许多CNS治疗方法都不成功。