2008 Barriers of the CNS Gordon Research Conference

2008 CNS 戈登研究会议的障碍

• 批准号: 7476625
• 负责人: THOMAS Paul DAVIS
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476625
• 关键词: Address; Alzheimer' s Disease; Area; Basic Science; Blood; Blood - brain barrier anatomy; Brain; Central Nervous System Diseases; Clinical; Communities; Disease; Future; Goals; Health; Image; Inflammation; International; Knowledge; Maps; Neuraxis; New Hampshire; Numbers; Participant; Patients; Pharmaceutical Preparations; Play; Public Health; Regulation; Request for Proposals; Research; Research Personnel; Retinal; Role; Schools; Spinal Neoplasms; Stroke; Structure of choroid plexus; Therapeutic; Tight Junctions; Work; day; neurovascular unit; programs; symposium

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting to be held on Barriers of the Central Nervous System (CNS) in Tilton, New Hampshire on June 22 to 27, 2008. The broad and long term goal of this conference is to increase our understanding of the fundamental mechanisms associated with the blood brain barrier (BBB)/neurovascular unit (NVU) in health and disease. One of the primary goals of this meeting is to understand why the BBB excludes important therapeutics from entering the brain of people afflicted with diseases of the CNS. The issue of CNS disease states and the role the BBB/NVU plays in these disease states is the central theme of our meeting. The Gordon Research Conference (GRC) on Barriers of the CNS is unique because it brings together (equally) both clinical and basic science researches in a format where full and honest exchange occurs on subjects important to the patient. It is to our mutual benefit that we work together to solve the long term problem associated with an inability to treat CNS disease states because of our paucity of knowledge about the BBB/NVU. The Specific Aims of this meeting will be to convene 45 speakers that present critical areas of both basic and clinical disease research with a total of 150 participants for a five day conference in the isolated and private setting of Tilton School, Tilton, New Hampshire. The program will have two keynote addresses and eight sessions that broadly address current issues in BBB Tight Junctions and Barrier Regulation, BBB Transporters and Barrier Functions, Choroid plexus/Blood-CSF Barrier in health and disease, BBB/NVU imaging, retinal-, spinal-, and tumor barriers, BBB/NVU in stroke, BBB/NVU in Alzheimer's disease, and the BBB/NVU in inflammation. The significance of this application is that the GRC on Barriers of the CNS is one half of the total number of conferences offered in the area of Barriers of the CNS. Only one other conference is offered and it is offered in alternate years to the GRC. This GRC is our only conference every two years. This GRC conference propels research in the international community of BBB/NVU researchers. The health relatedness of this application is clear. Discussions will define strategies to treat CNS disease states with drugs. Discussions at GRC will map the future for defining how to understand CNS disease states and the BBB/NVU and discuss why many CNS therapeutics have been unsuccessful to date. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is clear. Discussions will define strategies to treat CNS disease states with drugs. Discussions at GRC will map the future for defining how to understand CNS disease states and the BBB/NVU and discuss why many CNS therapeutics have been unsuccessful to date.

描述(由申请人提供)：本提案请求部分支持将于2008年6月22日至27日在新罕布夏州蒂尔顿举行的关于中枢神经系统障碍的国际会议。本次会议的广泛和长期目标是增进我们对与血脑屏障(BBB)/神经血管单位(NVU)在健康和疾病中相关的基本机制的理解。这次会议的主要目标之一是了解为什么血脑屏障排除了重要的治疗方法进入患有中枢神经系统疾病的人的大脑。中枢神经系统疾病状态的问题以及BBB/NVU在这些疾病状态中所起的作用是我们会议的中心主题。关于中枢神经系统障碍的戈登研究会议(GRC)是独一无二的，因为它(平等地)将临床和基础科学研究聚集在一起，在这种形式下，就对患者重要的主题进行全面和诚实的交流。我们共同努力解决由于我们对BBB/NVU缺乏了解而无法治疗CNS疾病状态的长期问题，这对我们双方都有利。这次会议的具体目标是召集45位演讲者，介绍基础和临床疾病研究的关键领域，共有150名与会者，在新罕布夏州蒂尔顿的蒂尔顿学校与世隔绝的私人环境中举行为期五天的会议。该计划将有两个主题演讲和八个会议，广泛讨论当前的问题，包括血脑屏障紧密连接和屏障调节，血脑屏障转运体和屏障功能，脉络丛/血-脑脊液屏障与健康和疾病，血脑屏障/NVU成像，视网膜，脊柱和肿瘤屏障，BBB/NVU在中风，BBB/NVU在阿尔茨海默病，以及BBB/NVU在炎症中。这一申请的意义在于，关于CNS障碍的GRC是在CNS障碍领域提供的会议总数的一半。只有一次其他会议提供，并每隔一年向GRC提供。这次GRC是我们每两年举行的唯一一次会议。这次GRC会议推动了BBB/NVU研究人员在国际社会的研究。这个应用程序与健康的相关性是显而易见的。讨论将确定用药物治疗中枢神经系统疾病状态的策略。GRC的讨论将描绘出未来如何定义如何理解CNS疾病状态和BBB/NVU，并讨论为什么到目前为止许多CNS疗法都不成功。公共卫生相关性：该应用程序的健康相关性是显而易见的。讨论将确定用药物治疗中枢神经系统疾病状态的策略。GRC的讨论将描绘出未来如何定义如何理解CNS疾病状态和BBB/NVU，并讨论为什么到目前为止许多CNS疗法都不成功。