10th International Meeting on Human Genome Variation and Complex Genome (HGV2008)

描述（由申请人提供）：本提案寻求NHGRI资助，以部分支持来自代表性不足群体的美国初级教师和美国实习生参加将于2008年10月15日至17日在加拿大多伦多Old Mill Inn举行的第10届人类基因组变异和复杂基因组分析国际会议（HGV2008）。随着2005年10月HapMap一期项目的完成和2007年10月HapMap二期结果的公布，人类基因组变异研究领域进展非常迅速，因此HGV2008会议特别及时。人们还日益认识到，基因组的拷贝数多态性和结构变异是人类进化的重要标志和人类疾病的原因。此外，最近已经发表了一些全基因组研究的结果，还有更多的全基因组研究正在进行中，这些研究的结果将在本次会议召开时准备好提交。在HGV2008中，我们将对人类变异研究的新兴领域进行大量报道，并将不同领域的研究人员聚集在一起，促进合作，推动该领域进一步发展。这个为期三天的会议的独特之处在于，它汇集了人类变异研究许多领域的顶尖研究人员，从将极大地改变该领域的全新技术，到不同类型的人类变异产生的机制，到考虑拷贝数变异的HapMap时代基因研究的新统计方法，再到基于比较基因组变异分析的分子进化研究，以及人类变异研究的社会和伦理意义。

DESCRIPTION (provided by applicant): This proposal seeks NHGRI funding to partially support US junior faculty members from under-represented groups and US trainees to attend the 10th International Meeting on Human Genome Variation and Complex Genome Analysis (HGV2008) to be held at the Old Mill Inn in Toronto, Canada from October 15-17, 2008. The HGV2008 meeting is particularly timely because the field of human genome variation research is moving very fast, with the completion of the HapMap Phase I Project in October 2005 and the publication of the HapMap Phase II results in October 2007. There is also increasing recognition that copy number polymorphisms and structural variations of the genome are important signatures of human evolution and causes of human diseases. In addition, results from a number of genome-wide studies have been published recently and many more genome-wide studies are underway and the results of these studies will be ready for presentation by the time this meeting is held. In HGV2008, we will devote substantial coverage of the emerging areas of human variation research and bring together investigators in diverse fields to promote collaborations and move the field even further along. The unique feature of this three-day meeting is that it brings together top researchers in the many areas of human variation research, from radically new technologies that will change the field dramatically, to the mechanisms of how different types of human variations came about, to new statistical approaches for genetic studies in the HapMap era that take into account copy number variations, to the study of molecular evolution based on comparative genome variation analysis, and to the social and ethical implications of human variation research. Performance site: The Old Mill Inn, Toronto, Canada Key Personnel: Pui-Yan Kwok, M.D., Ph.D. UCSF P.I. Stephen J. Chanock, M.D. NIH, NCI Co-PI Public Health Relevance In the fast moving field of human variation, this meeting brings together experts of different parts of the research area with the common goal of identifying the genetic factors that influence human health and disease. The research collaborations resulting from this meeting will hasten the arrival of personalized medicine, an era when we, based on our genetic make-up, modify our life styles to promote health and prevent disease. If we do get sick, our treatments are guided by our genetic profile so that the most beneficial medication are given at the right dose and with minimal risk of adverse side effects.