MOLECULAR MEMBRANE BIOLOGY PROGRAM

分子膜生物学（MMB）计划为AECC研究人员提供了一个长期的论坛 主要兴趣在于确定在细胞表面或细胞膜中起作用的分子在癌症中的作用。 哺乳动物细胞的分泌途径。目标是确定结构/功能关系， 存在于细胞膜或包膜病毒中的分子，并利用其在癌症中的特性 诊断、预后或治疗。在过去的5年里，项目成员已经确定了新的机制， 肿瘤发生、肿瘤进展、血管生成和转移以及对 化疗药物该小组现由18名成员组成，包括4名新小学生和1名新 二级委员，来自11个部门。二级任命者来自医学系， 儿科和肿瘤学。不幸的是，去年有两名成员意外去世。另一成员 没有被AECC更新，一名成员被转移到另一个癌症中心。在上一个预算年度， 成员们得到了10项NCI赠款（240万美元直接资助）、一项Susan科门奖和另外15项NIH资助 赠款。大约三分之一的MMB小组研究膜转运蛋白，包括Na+/l-同向转运蛋白 (NIS)，葡萄糖转运蛋白（GLUT 4和GLUTS），叶酸转运蛋白，F1/FO ATP合酶，多药耐药 抗性转运蛋白、前列腺素转运蛋白和Na+/单羧酸转运蛋白（SMCT）。 几个成员研究膜运输和分泌的机制，包括两个病毒学家 研究导致癌症的病毒中的病毒组装和膜融合机制， 属于致癌病毒家族另一个焦点是由N聚糖介导的细胞表面相互作用， Notch受体、钙粘蛋白和半乳糖凝集素。该小组在《癌症杂志》上发表了189篇与癌症相关的论文。 过去5年; 12%为方案内合作，29%为方案间合作。未来目标 MMB计划的目的是促进发现膜分子在癌症诊断中的新作用， 预后和治疗的临床应用，以扩大该计划，包括科学家调查 整合素和选择素在癌症中通过新的募集，并增强与肿瘤的相互作用 微环境和转移组，以扩大细胞-细胞癌症研究的范围 相互作用和膜相关现象。

The Molecular Membrane Biology (MMB) Program provides a long-standing forum for AECC investigators with a primary interest in determining roles in cancer for molecules that function at the cell surface or in the secretory pathway of mammalian cells. The goals are to determine structure/function relationships of molecules that reside in cell membranes or enveloped viruses, and to exploit their properties in cancer diagnosis, prognosis or treatment. In the past 5 years program members have identified new mechanisms of tumorigenesis, tumor progression, angiogenesis and metastasis and mechanisms of resistance to chemotherapeutic drugs. The group now comprises 18 members, including 4 new primary and one new secondary member, from 11 departments. Secondary appointees are from the Departments of Medicine, Pediatrics and Oncology. Sadly two members unexpectedly passed away in the last year. Another member was not renewed by AECC and one member moved to another cancer center. In the last budget year, MMB members were supported by 10 NCI grants ($2.4M direct), a Susan Komen award, and an additional 15 NIH grants. About a third of the MMB group investigates membrane transporters, including the Na+/l- symporter (NIS), glucose transporters (GLUT4 and GLUTS), folate transporters, the F1/FO ATP synthase, a multi-drug resistance transporter, prostaglandin transporters and the Na+/monocarboxylate transporter (SMCT). Several members investigate mechanisms of membrane trafficking and secretion including two virologists investigating mechanisms of virus assembly and membrane fusion in viruses that either cause cancer, or belong to a family of viruses that cause cancer. Another focus is on cell surface interactions mediated by Nglycans, Notch receptors, cadherins, and galectins. The group published 189 cancer relevant papers in the last 5 years; 12% represented intraprogrammatic, and 29% interprogrammatic, collaborations. Future goals for the MMB program are to catalyze discoveries of new roles for membrane molecules in cancer diagnosis, prognosis and treatment to clinical applications, to expand the program to include scientists investigating integrins and selectins in cancer through new recruitment, and to enhance interactions with the Tumor Microenvironment and Metastasis group in order to expand the scope of cancer research in cell-cell interactions and membrane-related phenomena.