CELL GROWTH & DIFFERENTIATION

细胞生长和分化控制计划成员的研究重点是识别和 了解控制增殖、分化和分化的细胞因子的作用机制 细胞死亡，控制这些过程的程序是如何协调的，以及它们如何相互作用。少校 科学目标是：(1)鉴定、表征和研究基因产品的作用机制 控制细胞增殖、谱系承诺和细胞分化，以及细胞死亡；(2)了解 这些基因产物和过程的错误调控如何促进肿瘤发生；(3)利用这一点 开发癌症预防和治疗新方法的知识。一个主要的科学焦点是 程序化是调控基因表达在细胞周期、分化和凋亡中的关键作用 转录因子在调节这些过程中扮演的角色。该计划的许多成员也是 研究表观遗传机制在癌症中的作用，包括组蛋白模式的变化 癌细胞中的修饰和DNA甲基化。一种全基因组甲基化分析的新方法 已由计划成员为这些研究开发，并与高度通用的阵列一起开发 平台，正被用于研究正常细胞生长和发育过程中的基因表达和表观遗传变化 在各种恶性肿瘤和癌前状态下的分化。在该计划中，有 特别擅长研究干细胞的特性，包括成人干细胞和人类胚胎干细胞 细胞，以及三个器官系统：造血系统、肝脏和神经细胞。这个 该计划受益于其研究计划利用非哺乳动物模式生物的成员 包括酵母、果蝇和斑马鱼。该小组成员的研究也得到了加强 在研究基因表达控制的最先进方法方面有专长的研究人员 真核细胞。目前有来自10个部门的26名计划成员，其中25名是主要成员 成员，由9个NCI(180万美元直接资助)和33个其他NIH赠款支持。已经有5名新员工加入 这个节目。自上次CCSG审查以来，已有439篇与癌症相关的研究论文 这一方案的成员中，8%代表方案内成员，20%代表方案间成员 合作。

Research by members of the Cell Growth and Differentiation Control Program is focused on identifying and understanding the mechanisms of action of the cellular factors that control proliferation, differentiation and cell death, how the programs controlling these processes are coordinated and how they interact. The major scientific goals are: (1) to identify, characterize and study the mechanisms of action of gene products controlling cell proliferation, lineage commitment and cell differentiation, and cell death; (2) to understand how misregulation of these gene products and processes contribute to oncogenesis; (3) to use this knowledge to develop new approaches to cancer prevention and treatment. A major scientific focus of the program is the control of gene expression during the cell cycle, differentiation and apoptosis and the key role played by transcription factors in regulating these processes. Many members of the program are also studying the role of epigenetic mechanisms in cancer, including changes in the patterns of histone modifications and DMA methylation in cancer cells. A new method for genome-wide methylation analyses has been developed by a program member for these studies and, along with a highly versatile array platform, is being used to study gene expression and epigenetic changes during normal cell growth and differentiation in a variety of malignancies and premalignant conditions. Within the program there are particular strengths in studying the properties of stem cells, both adult stem cells and human embryonic stem cells, as well as in three organ systems: the hematopoietic system, the liver, and neuronal cells. The program has benefited from members whose research programs utilize nonmammalian model organisms including yeast, Drosophila, and zebrafish. The research of the group's members is also strengthened by investigators with expertise in the most advanced approaches for studying control of gene expression in eukaryotic cells. There are currently 26 program members from 10 departments, of whom 25 are primary members, supported by 9 NCI ($1.8M Direct) and 33 other NIH grants. There have been 5 new recruits to this program. Since the last CCSG review there have been 439 cancer-relevant research papers by members of this program of which 8% represent intraprogrammatic, and 20% represent interprogrammatic collaborations.