CELL GROWTH & DIFFERENTIATION

细胞生长和分化控制计划成员的研究重点是识别和 了解控制增殖、分化和增殖的细胞因子的作用机制， 细胞死亡，控制这些过程的程序如何协调以及它们如何相互作用。主要 科学目标是：（1）鉴定、表征和研究基因产物的作用机制 控制细胞增殖、谱系定型和细胞分化以及细胞死亡;（2）了解 这些基因产物和过程的失调如何导致肿瘤发生;（3）使用这种方法 开发癌症预防和治疗新方法的知识。一个主要的科学焦点， 程序是控制基因表达在细胞周期、分化和凋亡过程中的关键作用 转录因子在调节这些过程中发挥的作用。该计划的许多成员也是 研究表观遗传机制在癌症中的作用，包括组蛋白模式的变化， 癌细胞中的DNA修饰和DNA甲基化。一种新的全基因组甲基化分析方法 是由一名项目成员为这些研究开发的，沿着一个高度通用的阵列 该平台被用于研究正常细胞生长过程中的基因表达和表观遗传变化， 在各种恶性肿瘤和癌前病变中的分化。在该方案中， 在研究干细胞的特性方面具有特殊优势，包括成体干细胞和人类胚胎干细胞 细胞，以及三个器官系统：造血系统，肝脏和神经元细胞。的 该计划受益于其研究计划利用非哺乳动物模式生物的成员 包括酵母果蝇和斑马鱼小组成员的研究也得到加强， 研究人员在最先进的方法研究基因表达控制的专业知识， 真核细胞目前有来自10个部门的26名计划成员，其中25名是小学生 成员，由9个NCI（180万美元直接）和33个其他NIH赠款支持。有5名新成员 这个戒酒会这自上次CCSG审查以来，已有439篇癌症相关研究论文， 该计划的成员，其中8%代表计划内，20%代表计划间 合作。

Research by members of the Cell Growth and Differentiation Control Program is focused on identifying and understanding the mechanisms of action of the cellular factors that control proliferation, differentiation and cell death, how the programs controlling these processes are coordinated and how they interact. The major scientific goals are: (1) to identify, characterize and study the mechanisms of action of gene products controlling cell proliferation, lineage commitment and cell differentiation, and cell death; (2) to understand how misregulation of these gene products and processes contribute to oncogenesis; (3) to use this knowledge to develop new approaches to cancer prevention and treatment. A major scientific focus of the program is the control of gene expression during the cell cycle, differentiation and apoptosis and the key role played by transcription factors in regulating these processes. Many members of the program are also studying the role of epigenetic mechanisms in cancer, including changes in the patterns of histone modifications and DMA methylation in cancer cells. A new method for genome-wide methylation analyses has been developed by a program member for these studies and, along with a highly versatile array platform, is being used to study gene expression and epigenetic changes during normal cell growth and differentiation in a variety of malignancies and premalignant conditions. Within the program there are particular strengths in studying the properties of stem cells, both adult stem cells and human embryonic stem cells, as well as in three organ systems: the hematopoietic system, the liver, and neuronal cells. The program has benefited from members whose research programs utilize nonmammalian model organisms including yeast, Drosophila, and zebrafish. The research of the group's members is also strengthened by investigators with expertise in the most advanced approaches for studying control of gene expression in eukaryotic cells. There are currently 26 program members from 10 departments, of whom 25 are primary members, supported by 9 NCI ($1.8M Direct) and 33 other NIH grants. There have been 5 new recruits to this program. Since the last CCSG review there have been 439 cancer-relevant research papers by members of this program of which 8% represent intraprogrammatic, and 20% represent interprogrammatic collaborations.