Sdl: a model for lymphocytic leukemia

描述（由申请人提供）： 我们正在通过研究自发显性白血病（Sdl）小鼠突变体来阐明白血病形成的遗传基础。Sdl突变出现在我们群体中雄性繁殖者的生殖系中，并导致遗传突变的小鼠在生命早期发生高度渗透性淋巴细胞白血病。在该模型中，生殖系遗传与接近100%的疾病转移率相结合，提供了一种独特的情况，允许分析这些小鼠造血系统中的肿瘤前状态。在Sdl小鼠中经历转化的细胞中的早期分子变化可以作为人类早期疾病存在的生物标志物。我们假设，研究Sdl小鼠将确定参与淋巴细胞白血病的启动和进展的遗传事件，并可能确定一个新的人类白血病癌基因。

DESCRIPTION (provided by applicant): We are elucidating the genetic basis of leukemia formation by studying the Spontaneous dominant leukemia (Sdl) mouse mutant. The Sdl mutation arose in the germline of a male breeder in our colony, and results in highly penetrant lymphocytic leukemia early in life in mice that inherit the mutation. The germline inheritance combined with disease penetrance approaching 100% in this model provides a unique situation that allows the pre-neoplastic state in the hematopoietic system of these mice to be analyzed. Early molecular changes in cells that will undergo transformation in Sdl mice could serve as biomarkers for the presence of early disease in humans. We hypothesize that studying the Sdl mouse will identify genetic events involved in lymphocytic leukemia initiation and progression and will potentially identify a new human leukemia oncogene.