Variations in Colonoscopy Screening: A Population Based Study

描述（由申请人提供）：结肠镜检查提供了发现和切除息肉的机会，从而可以预防结直肠癌（CRC）的发展。结肠镜检查不是一种无限的资源。其合理利用是优化结直肠癌筛查的关键。结肠镜检查实践和结果存在很大差异。了解这些变化和促成最有效和最有效结果的因素将为社区和学术环境中适当的CRC筛查提供信息。通过这一创新项目，我们将通过扩大新罕布什尔州（NH）结肠镜检查登记，包括高比例的新罕布什尔州结肠镜检查医师，将结肠镜检查结果与患者因素和病理结果联系起来，来描述新罕布什尔州（NH）成年人口的结肠镜检查实践、结果及其变化。这种描述将是动态的，涉及当前的实践以及实践如何随着时间的推移而演变，包括CT结肠镜和粪便DNA分析等新兴技术的影响。随着研究结果的积累，我们将与主要利益相关者探讨其影响，从而更好地理解和未来的质量改进和研究项目，以改善结肠镜检查的提供，以控制结直肠癌。这项工作是在过去十年中基于人群的乳房x光检查登记工作的启发下进行的。其中之一，NH乳房x线照相术网络，将为该项目提供经过验证的方法、实践经验和生产力记录。NH乳房x光检查登记处的主要研究者和工作人员在结肠镜检查的新工作中发挥了积极和实质性的作用。目的1：确定息肉切除术的发生率、类型、病理结果、完成率以及筛查、监测和诊断结肠镜检查的并发症，包括调整患者风险因素，使用基于州的结肠镜检查登记。目的2：检查结肠镜医师对重复检查时间的建议与针对特定患者亚组的公认指南之间的差异。目标3：确定目标1和目标2中确定的变异来源，包括患者、结肠镜医师和实践环境因素在多大程度上起作用，并有可能进行修改。目标4：与主要利益相关者（结肠镜医生、初级保健临床医生和社区成员）分享目标1-3的发现，探讨他们对这些发现的影响的看法，并就后续建议中可能涉及的干预机会提出见解。目标5：探索在学术和社区环境中应用的新兴技术对结肠镜检查的影响。公共卫生相关性：结直肠癌是主要杀手，结肠镜检查是目前我们最好的防御手段。受基于人群的乳房x光检查登记所带来的乳腺癌防治进展的启发和启发，该项目将创建一个结肠镜检查登记，以促进我们对有代表性的社区和学术环境如何提供结肠镜检查、目前取得的成果以及随着技术进步实践如何演变的理解。为了促进创新，医生和社区利益相关者将参与解释研究结果，并制定提高其质量和适当使用所需的行动。

DESCRIPTION (provided by applicant): Colonoscopy affords the opportunity for detection and removal of polyps and thus can prevent the development of colorectal cancer (CRC). Colonoscopy is not an unlimited resource. Its appropriate utilization is critical to optimizing CRC screening. Wide variations exist in colonoscopy practice and outcomes. Understanding these variations and the factors contributing to the most effective and efficient outcomes would inform appropriate CRC screening in both community and academic settings. Through this innovative project we will characterize colonoscopy practices, outcomes and their variations for the New Hampshire (NH) adult population by expanding the NH Colonoscopy Registry to include a high proportion of NH colonoscopists, linking colonoscopy findings with patient factors and pathology results. This characterization will be dynamic, addressing current practices and how practices evolve over time including the impact of emerging technologies such as CT colonography and fecal DNA analysis. As findings accrue, we will explore their implications with key stakeholders leading to better understanding and to future quality improvement and research projects that improve the provision of colonoscopy to control CRC. This work is informed and inspired by work of population-based mammography registries over the past decade. One of these, the NH Mammography Network, will provide proven methods, practical experience, and a record of productivity to this project. The NH Mammography Registry principal investigator and staff play active and substantial roles in this new work on colonoscopy. Project aims include: AIM 1: To identify polypectomy rates, types of polypectomies, pathology findings, completion rates, and complications for screening, surveillance, and diagnostic colonoscopy, including adjustment for patient risk factors, using a state-based colonoscopy registry. AIM 2: To examine discrepancies between colonoscopists' recommendations for timing of repeat exams and recognized guidelines for specific patient subgroups. AIM 3: To identify sources of variation identified in Aim 1 and Aim 2, including the degree to which patient, colonoscopist, and practice setting factors contribute and have the potential for modification. AIM 4: To share findings from Aims 1-3 with key stakeholders (colonoscopists, primary care clinicians, and community members), explore their views on the implications of these findings, and develop insights on opportunities for intervention that could be addressed in subsequent proposals. AIM 5: To explore the impact of emerging technologies on colonoscopy as applied in both academic and community-settings. PUBLIC HEALTH RELEVANCE: Colorectal cancer is a major killer and colonoscopy is currently our best defense. Inspired and informed by the progress against breast cancer that has resulted from population- based mammography registries, this project will create a colonoscopy registry to advance our understanding of how it is provided in representative community and academic settings, the outcomes it currently achieves, and how the practice evolves as technology advances. To spur innovations, physician and community stakeholders will be engaged in interpreting the findings and developing actions needed to increase its quality and appropriate use.