Detector Module for Portable PET Scanner

描述（由申请人提供）：我们将设计和评估一种用于PET的新型探测器模块，并证明它将显著提高灵敏度和分辨率，同时使PET结构紧凑、重量轻、便携。提出的基本探测器元件是基于使用一种新型的光探测器称为固态光电倍增器（SSPM）和LYSO闪烁晶体。滨松为我们公司开发了一种特殊的陶瓷安装SSPM。其紧凑的尺寸（2.4x1.9x0.85 mm）使PET扫描仪的分辨率接近1毫米。其厚度（0.85 mm）允许多层探测器沿径向放置，从而实现相互作用和晶间散射事件的深度。该项目第一阶段的具体目标是通过模拟以及各种探测器布置的实验来研究以下方面的改进程度：1）空间分辨率，2）灵敏度，3）晶间散射校正，4）相互作用深度识别，5）散射事件抑制，6）通过改进的时间分辨率来抑制单次。第一阶段计划的实验和模拟旨在使我们能够为第二阶段建立最佳的探测器配置。意义：在各种临床条件下，术中准确的肿瘤定位至关重要。使PET适应手术室的能力将允许产生肿瘤的真实的时间功能图像，从而允许更好的肿瘤定位。相同的探测器模块可以作为便携式PET的其他更大配置的基础，极大地扩展了PET在各种环境中的应用。

DESCRIPTION (provided by applicant): We will design and evaluate a novel detector module for PET, and demonstrate that it would significantly increase the sensitivity and resolution, while making PET compact, light weight, and portable. The basic detector element proposed is based on the use of a novel light-detector called Solid State Photo- multiplier (SSPM) and LYSO scintillation crystals. Hamamatsu has developed a special ceramic-mounted SSPM for our company. Its compact size (2.4x1.9x0.85 mm) enables construction of PET scanners with a resolution close to a millimeter. Its thinness (0.85 mm) allows multiple layer of the detectors to be put in radial direction enabling the depth of interaction and inter-crystal scatter events. The specific aims of the Phase I of this project are to study, both through simulation as well as experiments with a variety of detector arrangements, the degree of improvements in: 1)- Spatial resolution, 2)- Sensitivity, 3)- Inter-crystal scatter correction, 4)- Depth of interaction identification, 5)- Scatter events rejection 6)- Singles rejection by improved time resolution. The experiments and simulations planned for the Phase I are directed to enable us to build the optimum detector configurations for the Phase II. Significance: Accurate intra-operative tumor localization is critical in a variety of clinical conditions. The ability to adapt PET to the operating room would allow for the generation of real time functional images of tumors , allowing for better tumor localization. The same detector module can be the basis of other larger configurations of portable PET, greatly expanding the application of PET in a variety of settings.