Robust Wide-Angle Spectral Domain OCT Arthroscope for Operative Imaging and Guida

用于手术成像和 Guida 的稳健广角频域 OCT 关节镜

• 批准号: 7484456
• 负责人: Sunita Sayeram
• 金额: $ 20.12万
• 依托单位: BIOPTIGEN, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7484456
• 关键词: Arthroscopes; Arthroscopic Surgical Procedures; Arthroscopy; Businesses; Cartilage; Chondrocytes; Clinical; Compatible; Condition; Debridement; Degenerative polyarthritis; Development; Diagnosis; Disease; Early Diagnosis; Epidemic; Evaluation; Facility Construction Funding Category; Growth Factor; Histology; Image; Imagery; Knee; Knee bone; Laboratories; Magnetic Resonance Imaging; Mechanics; Metabolic; Miniaturization; Monitor; Optical Coherence Tomography; Optics; Orthopedics; Pathogenesis; Patients; Phase; Principal Investigator; Rate; Research; Resolution; Rotation; Scanning; Signal Transduction; Site; Speed; Standards of Weights and Measures; Sterilization for infection control; Surface; Surgeon; System; Technology; Testing; Tissues; United States; articular cartilage; base; design; disabling disease; ergonomics; experience; improved; innovation; lens; novel; professor; programs; prototype; tissue phantom; tool; transmission process

DESCRIPTION (provided by applicant): This Phase I Small Business Innovative Research application proposes to develop a robust spectral domain optical coherence tomography (SDOCT) system suitable for combined diagnosis and treatment monitoring of osteoarthritis. Osteoarthritis is reaching epidemic proportions in the United States. Difficulty in diagnosing cartilage degeneration prior to the development of irreversible changes is a major obstacle to development and evaluation of disease modifying treatments for osteoarthritis. The earliest signs of degeneration occur prior to breakdown of the articular surface and include microstructural changes that are difficult to detect by radiographs, standard arthroscopy, or conventional magnetic resonance imaging (MRI). Orthopaedic surgeons perform over 650,000 arthroscopies a year for knee problems and find visible cartilage damage in up to 80% of patients. Professor Constance Chu, a subcontractor on this application, has shown that OCT can be used arthroscopically to nondestructively image articular cartilage at resolutions comparable to low power histology, and that OCT detectable changes found in the laboratory to indicate potentially reversible early cartilage insensitivity to anabolic growth factors were more prevalent in patients undergoing arthroscopic surgery for conditions associated with early degenerative joint disease. Because early chondrocyte metabolic incompetence has been implicated in the pathogenesis of osteoarthritis, these findings support the hypothesis that OCT can be used clinically to improve arthroscopic diagnosis of early articular cartilage degeneration. This proposal aims to develop novel clinical technology for arthroscopic OCT by developing new rigid borescope technology for sub-surface visualization of cartilage surfaces, synergizing the OCT probe with arthroscopic tools used for debridement, and reconfiguration/miniaturization of components to permit easy and frequent sterilization of the entire probe.

描述（由申请人提供）：I阶段小型企业创新研究申请提议开发适用于合并诊断和治疗骨关节炎治疗监测的稳健光谱域光学连贯性断层扫描（SDOCT）系统。在美国，骨关节炎正在达到流行比例。在不可逆变化发展之前诊断软骨变性的困难是开发和评估疾病修饰治疗骨关节炎的主要障碍。最早的变性迹象发生在关节表面崩溃之前，包括微观结构变化，这些变化很难通过X光片，标准关节镜检查或常规的磁共振成像（MRI）检测到。骨科医生每年对膝关节问题进行65万多个关节镜检查，并发现多达80％的患者可见软骨损伤。该应用程序上的分包商康斯坦斯·楚（Constance Chu）教授表明，可以通过与低功率组织学相媲美的分辨率进行关节镜以非破坏性图像关节软骨，并且在实验室中发现的OCT可检测变化表明，与患者相关的疾病中的疾病中有更多的疾病，可能对早期的软骨对疗程的疾病进行了良好的疾病。由于早期的软骨细胞代谢无能与骨关节炎的发病机理有关，因此这些发现支持了以下假设：临床上可以将OCT用于改善早期关节软骨变性的关节镜诊断。该建议旨在通过开发新的刚性孔技术来开发新型的关节镜临床技术，用于软骨表面的地下可视化，从而使用用于筹集的关节镜工具来使OCT探针协同，并允许整个探针的易于且频繁地进行分类/频繁地进行分类。