Robust Wide-Angle Spectral Domain OCT Arthroscope for Operative Imaging and Guida

用于手术成像和 Guida 的稳健广角频域 OCT 关节镜

• 批准号: 7484456
• 负责人: Sunita Sayeram
• 金额: $ 20.12万
• 依托单位: BIOPTIGEN, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7484456
• 关键词: Arthroscopes; Arthroscopic Surgical Procedures; Arthroscopy; Businesses; Cartilage; Chondrocytes; Clinical; Compatible; Condition; Debridement; Degenerative polyarthritis; Development; Diagnosis; Disease; Early Diagnosis; Epidemic; Evaluation; Facility Construction Funding Category; Growth Factor; Histology; Image; Imagery; Knee; Knee bone; Laboratories; Magnetic Resonance Imaging; Mechanics; Metabolic; Miniaturization; Monitor; Optical Coherence Tomography; Optics; Orthopedics; Pathogenesis; Patients; Phase; Principal Investigator; Rate; Research; Resolution; Rotation; Scanning; Signal Transduction; Site; Speed; Standards of Weights and Measures; Sterilization for infection control; Surface; Surgeon; System; Technology; Testing; Tissues; United States; articular cartilage; base; design; disabling disease; ergonomics; experience; improved; innovation; lens; novel; professor; programs; prototype; tissue phantom; tool; transmission process

DESCRIPTION (provided by applicant): This Phase I Small Business Innovative Research application proposes to develop a robust spectral domain optical coherence tomography (SDOCT) system suitable for combined diagnosis and treatment monitoring of osteoarthritis. Osteoarthritis is reaching epidemic proportions in the United States. Difficulty in diagnosing cartilage degeneration prior to the development of irreversible changes is a major obstacle to development and evaluation of disease modifying treatments for osteoarthritis. The earliest signs of degeneration occur prior to breakdown of the articular surface and include microstructural changes that are difficult to detect by radiographs, standard arthroscopy, or conventional magnetic resonance imaging (MRI). Orthopaedic surgeons perform over 650,000 arthroscopies a year for knee problems and find visible cartilage damage in up to 80% of patients. Professor Constance Chu, a subcontractor on this application, has shown that OCT can be used arthroscopically to nondestructively image articular cartilage at resolutions comparable to low power histology, and that OCT detectable changes found in the laboratory to indicate potentially reversible early cartilage insensitivity to anabolic growth factors were more prevalent in patients undergoing arthroscopic surgery for conditions associated with early degenerative joint disease. Because early chondrocyte metabolic incompetence has been implicated in the pathogenesis of osteoarthritis, these findings support the hypothesis that OCT can be used clinically to improve arthroscopic diagnosis of early articular cartilage degeneration. This proposal aims to develop novel clinical technology for arthroscopic OCT by developing new rigid borescope technology for sub-surface visualization of cartilage surfaces, synergizing the OCT probe with arthroscopic tools used for debridement, and reconfiguration/miniaturization of components to permit easy and frequent sterilization of the entire probe.

描述（由申请人提供）：本I期小型企业创新研究申请旨在开发一种适用于骨关节炎联合诊断和治疗监测的稳健的谱域光学相干断层扫描（SDOCT）系统。骨关节炎在美国已达到流行病的程度。在发生不可逆变化之前诊断软骨变性的困难是开发和评价骨关节炎疾病改善治疗的主要障碍。退变的最早迹象发生在关节面破裂之前，包括难以通过X线片、标准关节镜检查或常规磁共振成像（MRI）检测到的显微结构变化。骨科医生每年为膝关节问题进行超过65万次关节镜检查，发现高达80%的患者有明显的软骨损伤。该申请的分包商Constance Chu教授已证明，OCT可用于关节镜下以与低倍组织学相当的分辨率对关节软骨进行非破坏性成像，并且在实验室中发现的OCT可检测变化表明，在因早期退行性关节疾病相关疾病而接受关节镜手术的患者中，可能可逆的早期软骨对合成代谢生长因子不敏感性更为普遍。由于早期软骨细胞代谢功能不全与骨关节炎的发病机制有关，因此这些发现支持了OCT可用于临床以改善早期关节软骨退变的关节镜诊断的假设。该提案旨在通过开发用于软骨表面亚表面可视化的新型刚性管道镜技术、协同OCT探头与用于清创的关节镜工具以及组件的重新配置/小型化以允许对整个探头进行简单和频繁的灭菌来开发关节镜OCT的新型临床技术。