Development of an Aging and Cancer Program at MSKCC

MSKCC 开发衰老和癌症项目

• 批准号: 6947740
• 负责人: GEORGE J. BOSL
• 金额: $ 61.86万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6947740
• 关键词: aging; clinical research; geriatrics; neoplasm /cancer; oncology

DESCRIPTION: (Applicant's Description) This application is submitted by Memorial Sloan Kettering Cancer Center (MSKCC) in response to RFA CA-03-504 (Planning and Development (P20) Grant Integrating Aging and Cancer research in NCI-Designated Cancer Centers). The goal of this Research Planning and Development application is to design and coordinate a research effort that will result in an research program encompassing aging and cancer integrated into its Cancer Center Support Grant (CCSG) over the next five years. To accomplish the task outlined in the RFA, a detailed timeline of planning and priority-setting activities has been set forth. The planning activities include the development of the infrastructure of the aging and cancer program; a plan for stimulating multi-disciplinary participation; establishment of a leadership group committed to a Program as defined by Cancer Center Support Grant guidelines; a process for the solicitation, review, and support for research proposals focused on cancer and aging; and a timetable of benchmarks for us to meet. This application will focus on the four thematic areas: 1) Treatment Efficacy and Tolerance; 2) Psychosocial Issues and Medical Effects; 3) Patterns of Care and 4) Biology of Aging and Cancer. Seventeen proposed protocols, including four pilot studies, indicate the interest and ongoing research activities at MSKCC. The rationale for developing these thematic areas in response to the research priorities described in the Workshop report is based on existing expertise, core resources, and patient population; quality of collaborative projects proposed by cancer center members in response to a Center-wide initiative; and the potential for unique collaboration with the Cornell Division of Geriatric Medicine and Gerontology. Since there are only two patient oriented research programs in the CCSG of MSKCC [Clinical Research (PI: G. J. Bosl MD) and Prevention, Control, and Population (C. Begg Ph.D.)], we will establish the equivalent of a CCSG-defined geriatrics program that is integrated through these clinical research programs, as well as the five basic and four bridging programs that comprise the CCSG at MSKCC. The leadership of MSKCC has committed itself to the recruitment of clinical and basic scientists over the next five years. Through this planning grant, MSKCC will formally expand its research activities in cancer biology and management in the aging population so that it will become a key component of its NCI-funded CCSG.

描述：(申请人描述)本申请由纪念斯隆-凯特琳癌症中心(MSKCC)为响应RFA CA-03-504(规划和发展(P20)在NCI指定的癌症中心整合老龄化和癌症研究的拨款)提交。这一研究规划和开发应用程序的目标是设计和协调一项研究工作，从而在未来五年内将一项围绕衰老和癌症的研究计划纳入其癌症中心支持赠款(CCSG)。 为了完成《区域行动方案》中概述的任务，制定了详细的规划和确定优先事项活动的时间表。规划活动包括发展老龄化和癌症计划的基础设施；刺激多学科参与的计划；建立一个领导小组，致力于癌症中心支持拨款指南所定义的计划；以癌症和老龄化为重点的研究提案的征求、审查和支持程序；以及我们要达到的基准的时间表。这项申请将集中在四个主题领域：1)治疗效果和耐受性；2)心理社会问题和医疗效果；3)护理模式；4)衰老和癌症生物学。17项拟议方案，包括4项试点研究，表明了MSKCC的兴趣和正在进行的研究活动。根据研讨会报告中描述的研究优先事项，开发这些专题领域的理由是基于现有的专业知识、核心资源和患者群体；癌症中心成员为响应中心范围的倡议而提出的合作项目的质量；以及与康奈尔老年医学和老年病学分部进行独特合作的潜力。由于MSKCC的CCSG中只有两个以患者为中心的研究计划[临床研究(PI：G.J.Bosl MD)和预防、控制和人口(C.Begg Ph.D.)]，我们将建立相当于CCSG定义的老年病学计划，通过这些临床研究计划以及组成MSKCC CCSG的五个基本和四个桥梁计划。MSKCC的领导层承诺在未来五年内招募临床和基础科学家。通过这笔规划拨款，MSKCC将正式扩大其在癌症生物学和老龄化人口管理方面的研究活动，使其成为NCI资助的CCSG的关键组成部分。