Administrative Core

行政核心

• 批准号: 7222482
• 负责人: MAKRIYANNIS ALEXANDROS
• 金额: $ 5.1万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7222482
• 关键词: Active Sites; Adenylate Cyclase; Advisory Committees; Affinity; Affinity Chromatography; Agonist; Antibodies; Area; Arts; Autoradiography; Binding; Binding Sites; Biochemical; Biochemistry; Brain; CNR1 gene; CNR2 gene; Cannabinoids; Cellular biology; Chemicals; Chemistry; Class; Collaborations; Communication; Complex; Computer Simulation; Core Facility; Data; Databases; Development; Digestion; Dimerization; Employee Strikes; Endocannabinoids; Ensure; Epitopes; Evaluation; Event; Facility Designs; Fc Receptor; Fluorine; Goals; Group Meetings; Growth; Human; Image; Individual; Interdisciplinary Study; Internet; Iodine; Label; Laboratories; Life; Ligand Binding; Ligands; Lipase; Maintenance; Mammalian Cell; Mediating; Methods; Modeling; Molecular; Occupational activity of managing finances; Operative Surgical Procedures; Papio; Participant; Peptide Fragments; Performance; Pharmacology; Positron-Emission Tomography; Preparation; Principal Investigator; Production; Property; Proteins; Public Health; Pyrazoles; Radioactivity; Radiolabeled; Radiopharmaceuticals; Receptor Activation; Recombinants; Records; Reporting; Research; Research Project Grants; Resource Sharing; Rodent; Role; Series; Signal Transduction; Signaling Protein; Site; Staging; Structure; System; Telephone; Therapeutic; Time; Transfection; Update; Work; analog; anandamide; authority; base; behavioral pharmacology; cannabinoid receptor; cost; density; desensitization; design; experience; fatty acid amide hydrolase; in vivo; interest; intravenous administration; lipophilicity; man; multidisciplinary; mutant; novel; programs; pyrazole; radioligand; radiotracer; receptor; repository; research study; single photon emission computed tomography; symposium

The Administrative Core (Core A) will serve as a centralized facility designed to manage all operations related to this PP and facilitate the interactions between the collaborating laboratories. The major tasks of this Core component will be to: a) communicate the central scientific theme to which all component projects will direct their research efforts; b) manage the fiscal aspects of the PP, maintain financial records and other administrative functions; and (c) promptly and properly distribute or coordinate the distribution of materials (chemicals, biologicals, ligands, radioligands, receptor mutants, antibodies, clones, etc.) produced under the auspices of Core B and the other projects. The Administrative Core will also take responsibility for synchronizing the operations and communications between the individual laboratories involved in the PP and other laboratories which interact collaboratively at no cost to the project. This effort will include recording and distributing materials produced to the participant laboratories and to the collaborating laboratories, together with maintaining and updating the data base related to this collaborative effort. Additional specific coordinating efforts will include regular telephone conferences, the yearly group meeting of participants and collaborators, as well as other communications, including the maintenance of a Web page dedicated to Program Project activities. The quarterly meetings with the Internal Advisory Committee, as well as the yearly formal meeting with the External Scientific Advisory Committee, will also be organized under Core A. The Administrative Core will maintain or increase the common or shared resources that are required for the performance of the inter-related tasks for the component research projects. General administrative support related to this Program Project, including financial management, correspondence, and preparation of reports and proposals, will also be provided by this Core Facility. The Core A proposal also includes a brief summary of all of the Program Project components and an outline of the scientific interactions between the participating laboratories, including lines of authority, program coordination and evaluation. The synergistic aspect of the different collaborations, all working in this specialized area of mutual scientific and public health interest, constitutes a major strength of this unique multidisciplinary research effort.

行政核心（核心A）将充当旨在管理所有操作的集中式设施 与此PP有关，并促进了协作实验室之间的互动。主要任务 该核心组成部分将是：a）传达所有组件项目的中心科学主题 将指导他们的研究工作； b）管理PP的财政方面，维护财务记录和其他 行政功能； （c）及时正确分发或协调材料的分布 （化学物质，生物学，配体，放射线，受体突变体，抗体，克隆等） 核心B和其他项目的主持人。行政核心还将负责 同步PP中涉及的各个实验室之间的操作和通信 其他实验室，这些实验室与项目无需合作。这项工作将包括记录 并分配给参与者实验室和合作实验室生产的材料， 以及维护和更新与此协作工作相关的数据库。其他具体 协调工作将包括定期电话会议，参与者的年度小组会议以及 合作者以及其他沟通，包括维护专门的网页 计划项目活动。与内部咨询委员会的季度会议以及 与外部科学咨询委员会的年度正式会议也将在Core A中组织。 行政核心将维护或增加所需的共同或共享资源 组件研究项目的相互关联任务的执行。一般行政支持 与此计划项目有关，包括财务管理，通信和报告的准备 和提案也将由该核心设施提供。 核心A提案还包括所有程序项目组件的简要摘要和一个 参与实验室之间的科学相互作用的概述，包括权威的线条， 计划协调和评估。不同合作的协同方面都在 这个相互科学和公共卫生的专业领域构成了这一独特的主要优势 多学科研究工作。