IMMUNOBIOLOGY OF SAIDS-ASSOCIATED LYMPHOMAS

SAIDS 相关淋巴瘤的免疫生物学

• 批准号: 7562246
• 负责人: Laura S Levy
• 金额: $ 7.16万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562246
• 关键词: Age; B-Lymphocytes; Cell Count; Cells; Clinical Course of Disease; Clinical Data; Computer Retrieval of Information on Scientific Projects Database; Control Animal; Data; Funding; Grant; Immunobiology; Immunohistochemistry; Institution; Laboratories; Lymphoma; Macaca mulatta; Output; Phenotype; Rate; Relative (related person); Research; Research Personnel; Resources; Simian Acquired Immunodeficiency Syndrome; Source; T-Lymphocyte; Techniques; Time; Tissues; United States National Institutes of Health; Work; case control; lymphoid hyperplasia; peripheral blood

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are continuing our collaborative project with Dr. Laura Levy in examining lymphomas in SIV-infected and uninfected rhesus macaques. To date, we have identified numerous cases of simian AIDS-related lymphoma (sARL) and are comparing age matched control animals for various laboratory and clinical data including survival time, absolute and relative B-cell and T-cell counts, rate of B-cell and T-cell change over the disease course, clinical evidence of lymphoid hyperplasia, and peripheral blood antigenemia. The data were than analyzed statistically in a case-control manner. The statistical analysis was recently completed, and proved to be exhaustive. At least 500 pages of output resulted, which we are continuing to analyze. We are also examining subsets of cells in lymphoma tissues by immunohistochemistry. Dr. Ivona Pandrea is also now working with Dr. Levy to phenotype lymphomas by various techniques.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在继续与Laura Levy博士的合作项目，检查SIV感染和未感染恒河猴的淋巴瘤。到目前为止，我们已经确定了许多猴艾滋病相关淋巴瘤（sARL）的病例，并比较了年龄匹配的对照动物的各种实验室和临床数据，包括生存时间，绝对和相对B细胞和T细胞计数，B细胞和T细胞在病程中的变化率，淋巴增生的临床证据，外周血抗原血症。 以病例对照的方式对数据进行统计学分析。 最近完成了统计分析，并证明是详尽无遗的。 至少产生了500页的输出，我们正在继续分析。我们还通过免疫组织化学检查淋巴瘤组织中的细胞亚群。 Ivona Pandrea博士现在也与Levy博士合作，通过各种技术对淋巴瘤进行表型分析。