EPOXYEICOSATRIENOIC ACID SYNTHESIS, METABOLISM & ACTION IN MAMMALIAN OVARIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 黄体是一个暂时的内分泌腺，由破裂的排卵卵泡残余物形成，是孕酮的主要来源，孕酮是所有哺乳动物物种支持怀孕所必需的激素。根据腺体的发育(黄体化)、维持和退化(黄体溶解)，这个腺体的寿命可以分为三个阶段。如果妊娠发生，黄体的适当发育和维持是建立和继续妊娠所必需的。在没有受精的情况下，黄体退化，从而启动下一个卵巢周期。脑垂体促黄体激素是灵长类动物黄体发育和维持的主要激素。虽然黄体生成素直接调节许多对灵长类黄体发育和功能至关重要的分子和细胞过程，但它的作用也可能通过局部因素(如旁分泌或自分泌作用物质)间接调节。然而，当地因素在灵长类黄体活动中的参与和作用却知之甚少。利用啮齿动物、驯养动物和灵长类动物进行的研究也表明，花生四烯酸衍生的前列腺素物种(即PGE2和PGF2pha)在黄体功能调节中具有重要作用。然而，在灵长类动物的黄体中，前列腺素的作用(S)仍然不明确。因此，利用基因组学方法来确定参与前列腺素合成、代谢和信号转导的编码基因在恒河猴月经周期的黄体中是否存在差异或协调调节。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The corpus luteum is a transient endocrine gland that forms from the remnants of the ruptured ovulatory follicle and is the primary source of progesterone, a hormone absolutely required to support pregnancy in all mammalian species. The lifespan of this gland can be divided into phases corresponding to its development (luteinization), maintenance, and regression (luteolysis). Proper development and maintenance of the corpus luteum is required for establishment and continuation of pregnancy if conception occurs. In the absence of fertilization, the corpus luteum regresses thus allowing for initiation of the next ovarian cycle. Pituitary-derived luteinizing hormone is the primary hormone responsible for corpus luteum development and maintenance in primates. While luteinizing hormone directly regulates many molecular and cellular processes that are critical for primate luteal development and function, its effects may also be mediated indirectly through local factors (e.g., paracrine or autocrine acting substances). The involvement and role of local factors in primate luteal activities, however, are poorly understood. From research utilizing rodents, domesticated animal species and primates, a significant role for arachidonate-derived prostaglandin species (i.e., PGE2 and PGF2alpha) in the regulation of luteal function has also been suggested. In the primate corpus luteum, however, the role(s) of prostaglandins remain poorly defined. Therefore, a genomic approach was utilized to determine if genes encoding proteins involved in prostaglandin synthesis, metabolism, and signaling are differentially or coordinately regulated in the corpus luteum through the menstrual cycle in rhesus macaques.