ADMINISTRATIVE CORE

核心C.管理核心。Darell D.Siger，医学博士，核心领导者。 请求为行政核心提供支助，包括为比格纳博士提供0.6个日历月的工作 SRC项目主任/首席研究员以及John H.Sampson，MD，Phd，MHSc，以协助Bigner博士 并担任SRC运营委员会的联合主席。比格纳博士和桑普森博士将提供 监督专门研究中心的科学和行政活动。比格纳医生会 他继续担任过去25年的主席，桑普森博士担任联合主席 SRC委员会，包括所有项目和核心领导(Zalutsky博士、Reardon博士和 麦克伦登)。它们将共同促进项目和核心之间的沟通和合作，并 监测和评估进展情况。比格纳博士和桑普森博士将每周与项目和核心领导人会面，并 将担任SRC活动产生的所有出版物的编辑审查小组。比格纳博士和 桑普森将与SRC计划和协调定期研讨会，包括内部和外部研讨会 演讲者，是每月神经肿瘤学计划研讨会系列的一部分。比格纳博士和 桑普森将协调SRC调查人员参加国家和国际研讨会， 关于脑瘤研究的会议。他们还将协调SRC的所有活动 内部和外部咨询委员会，并将作为SRC与其他适当学术机构的联络人 杜克大学内部的单位。与这笔赠款的前几年一样，请求提供一名工作人员专家的核心支助， 将负责安排所有内部和外部会议，预算监督和一般 行政协助。此外，还要求提供一名实验室技术员的支助，与前几年一样。 这笔赠款用于媒体解决方案、仪器和玻璃器皿准备的维护。核心C提供 支持所有三个研究项目和两个核心。核心C函数，其支持请求在 这份申请与过去五年的申请完全相同，只是桑普森博士的工作增加了 运营委员会联席主席。 相关性(请参阅说明)： 管理核心是协调项目中的所有活动所必需的，所有这些活动都是 旨在开发新的、更有效、毒性更低的恶性脑瘤治疗方法。此外，a 需要经过专门培训的技术人员为客户提供必要的解决方案和超净玻璃器皿 建议进行实验。

Core C. Administrative Core. Darell D. Signer, M.D., Ph.D., Core Leader. Support is requested for an Administrative Core including 0.6 calendar months effort for Dr. Bigner as SRC Program Director/Principal Investigator and for John H. Sampson, MD, PhD, MHScto assist Dr. Bigner and to serve as co-chair of the SRC Operations Committee. Drs. Bigner and Sampson will provide oversight of the scientific and administrative activities of the Specialized Research Center. Dr. Bigner will continue as he has for the past 25 years to chair, along with Dr. Sampson as co-chair, the Operations Committee for the SRC which includes all project and core leaders (Drs. Zalutsky, Reardon, and McLendon). Together they will foster communication and collaboration between the projects and cores and monitor and assess progress. Drs. Bigner and Sampson will meet weekly with project and core leaders and will serve as the editorial review team for all publications resulting from SRC activities. Drs. Bigner and Sampson will plan and coordinate regular seminars with the SRC, which will include internal and external speakers, and which are a part of the monthly Neuro-Oncology Program Seminar Series. Drs. Bigner and Sampson will coordinate the participation of SRC investigators in national and international workshops, conferences, and meetings on brain tumor research. They also will coordinate all the activities of the SRC Internal and External Advisory Committees and will serve as SRC liaisons with other appropriate academic units within Duke. Core support is requested for a Staff Specialist, as in previous years of this grant, who will be responsible for scheduling all internal and external meetings, budgetary monitoring, and general administrative assistance. Also, support is requested for a Laboratory Technician, as in previous years of this grant, for maintenance of media solutions, instrument, and glassware preparation. Core C provides support for all three research projects and two cores. Core C functions, for which support is requested in this application, are identical to those of the last five years with the addition of the effort for Dr. Sampson as co-chair of the Operations Committee. RELEVANCE (See instructions): The Administrative Core is necessary to coordinate all of the activities in the projects, all of which are designed to develop new and more effective and less toxic malignant brain tumor treatments. In addition, a specially trained technician is necessary to provide the necessary solutions and ultraclean glassware for the experiments proposed.