Development Research Program
发展研究计划
基本信息
- 批准号:7567939
- 负责人:
- 金额:$ 38.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-10-01 至 2013-09-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdenocarcinomaAdjuvantAdverse eventAerosolsAnimalsAwardAzacitidineBiological MarkersBloodBreathingCaliberCancer PatientCanis familiarisCharacteristicsDataDepositionDevelopmentDiseaseDrug FormulationsDrug KineticsEarly DiagnosisEventFosteringFoundationsFundingGene SilencingGenerationsGenesHalf-LifeHeadHistone Deacetylase InhibitorHumanHypermethylationKnowledgeLaboratoriesLiquid substanceLungMalignant neoplasm of lungMethodsMethylationModelingMyeloproliferative diseaseNebulizerNew MexicoParticle SizePathway interactionsPatientsPharmaceutical PreparationsPharmacologic SubstancePhase I Clinical TrialsPhase I/II TrialPilot ProjectsPropertyRattusRecurrenceReproduction sporesResearch InstituteResearch PersonnelResectedRodentRouteSignal PathwaySputumSquamous cell carcinomaStagingStructure of parenchyma of lungSubcutaneous InjectionsTechnologyTestingTherapeutic AgentsTimeToxicologyTranslatingTumor Suppressor GenesUnited States National Institutes of HealthUniversitiesWorkanticancer researchaqueouscancer therapycareerdemethylationefficacy testingin vivoinnovationinsightlymph nodesnanoparticlenonhuman primateprogramspromoterresearch and developmentrespiratorytumortumor growth
项目摘要
The developmental funds portion of our SPORE has proven to be one of the most vital aspects of our translational work in lung cancer. As will be detailed below, over the duration of the SPORE, several of our most productive full projects began as pilot projects funded through this Developmental Program. Also, this program has made possible the initiation of academic careers for multiple translational investigators who are now key players in this and other SPORES. It has also brought basic investigators to lung cancer research who might not have ever worked on these diseases. Finally, as will be evident below in the full presentation of three planned projects for the current proposal, we have used the Developmental Program mechanism to bring innovative new concepts and technology into the SPORE to foster our highest translational aims.
我们的SPORE的发展基金部分已被证明是我们在肺癌转化工作中最重要的方面之一。正如下文所述,在SPORE期间,我们的几个最具成效的完整项目开始作为通过该发展计划资助的试点项目。此外,该计划使多个翻译研究人员的学术生涯开始成为可能,他们现在是这个和其他SPORES的关键人物。它还为肺癌研究带来了可能从未研究过这些疾病的基础研究人员。最后,正如下面对当前提案的三个计划项目的完整介绍所示,我们使用发展计划机制将创新的新概念和技术引入SPORE,以促进我们的最高转化目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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STEPHEN B. BAYLIN其他文献
STEPHEN B. BAYLIN的其他文献
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{{ truncateString('STEPHEN B. BAYLIN', 18)}}的其他基金
Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer
用于确定和逆转导致结直肠癌风险的年龄相关表观遗传变化的类器官建模
- 批准号:
10206053 - 财政年份:2019
- 资助金额:
$ 38.04万 - 项目类别:
Characterizing age-associated epigenetic alterations and their roles in tumor development
表征与年龄相关的表观遗传改变及其在肿瘤发展中的作用
- 批准号:
9926803 - 财政年份:2019
- 资助金额:
$ 38.04万 - 项目类别:
Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer
用于确定和逆转导致结直肠癌风险的年龄相关表观遗传变化的类器官建模
- 批准号:
10657739 - 财政年份:2019
- 资助金额:
$ 38.04万 - 项目类别:
Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer
用于确定和逆转导致结直肠癌风险的年龄相关表观遗传变化的类器官建模
- 批准号:
10457265 - 财政年份:2019
- 资助金额:
$ 38.04万 - 项目类别:
(PQ4) - Tools for simultaneous disruption of multiple epigenetically silenced genes for studying their roles in tumorigenesis using ex vivo human and mouse colon organoid and in vivo mouse models
(PQ4) - 同时破坏多个表观遗传沉默基因的工具,用于使用离体人类和小鼠结肠类器官以及体内小鼠模型研究它们在肿瘤发生中的作用
- 批准号:
10471240 - 财政年份:2018
- 资助金额:
$ 38.04万 - 项目类别:
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