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Innovative Membrane Protein Tech: Sample Preparation IMP

Innovative Membrane Protein Tech: Sample Preparation IMP
创新膜蛋白技术:样品制备 IMP
批准号:
7114418
负责人:
GEOFFREY A CHANG
金额:
$37.99万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
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英文摘要
Aim 2. Develop novel methods and sample preparation reagents and tools for the stabilization of IMPs for structural biology studies. a. Lipid Chemistry - develop novel small molecule and polymeric compounds that extract and stabilize IMPs. b. Protein Stabilization Reagents - develop novel protein stabilization reagents (e.g. antibodies, rafts) that can be used to stabilize IMP preparations. c. Nanofabrication - develop novel tools to grow or analyze IMP samples using nanofabrication tools.
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Biosynthesis of marine terpenoid natural products
Synthetically-evolved and engineered Nanobodies selective for Cb isoforms of PKA
Nanobody inhibitors of proton-sensing G protein-coupled receptors
TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation
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