INBRE: CLEMSON U: ENHANCEMENT OF BIOENGINEERING AT CLEMSON UNIVERSITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 SC-INBRE项目的主题重点是“开发和应用生物工程”，总体重点是心血管疾病的再生医学。克莱姆森大学(CU)作为SC-INBRE联盟的团队成员，将通过建立“心血管生物材料核心”(CBC)，在心血管工程领域为创新生物材料的设计和表征提供领导地位。CBC将在生物材料设计方面向SC-INBRE联盟的研究人员提供支持，这些材料将用作细胞生长的支架或基质(推力I)、生物材料和工程组织的化学(推力II)和机械(推力III)表征，以及细胞-材料反应的组织技术分析(推力IV)。如有必要，推力研究人员将协助INBRE研究人员制定制备方法的方案。将视需要提供技术监督，以协助研究人员制定制样方案以及制样工作。此外，CU的机构布林指导委员会选择了三个有针对性的研究项目，因为它们在显著推进心血管生物工程研究的同时，具有增强CBC技术能力的巨大潜力。项目1涉及天然生物材料设计，项目2侧重于生物衍生涂层的开发及其表征，项目3研究心血管生物材料表面现象。 PI将担任项目总监。CU的INBRE活动将由克莱姆森大学路线图理事会和一个外部指导委员会密切监测。该计划的评估将由计划主任和PROSTER领导定期进行，以监测CBC研究人员(包括目标教师)的研究效率。成功的衡量标准将包括出版物、奖项、赠款提案提交和资金以及教育成果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The thematic focus for the SC-INBRE program is "Development and Applied Bioengineering" with a general focus on regenerative medicine for cardiovascular diseases. Clemson University (CU), as a team member of the SC-INBRE coalition, will provide leadership in cardiovascular engineering for the design and characterization of innovative biomaterials by establishing the "Cardiovascular Biomaterials Core" (CBC). The CBC will provide support to researchers of the SC-INBRE coalition in terms of design of biomaterials to be used as scaffolds or substrates for cell growth (Thrust I), chemical (Thrust II) and mechanical (Thrust III) characterization of biomaterials and engineered tissues, and histotechnological analysis of the cell-material reactions (Thrust IV). INBRE researchers will be assisted for protocol development for preparation methods if necessary by thrust researchers. Technical supervision will be provided as needed to assist researchers in the development of protocols for the preparation of samples, as well as sample preparation. Additionally, three targeted research projects have been selected by the Institutional BRIN Steering Committee at CU because of their high potential to enhance the technological capability of the CBC while significantly advancing cardiovascular bioengineering research. Project 1 addresses natural biomaterial design, Project 2 focuses on the development of biologically derived coatings and their characterization, and Project 3 investigates cardiovascular biomaterial surface phenomena. The PI will serve as the Program Director. The INBRE activities at CU will be closely monitored by the Clemson University Road Map Council and an external steering committee. Assessment of the program will be performed periodically by the Program Director and Thrust Leaders to monitor research productivity among CBC researchers including target faculty. Measures of success will include publications, awards, grant proposal submission and funding, and educational outcomes.