SYNTHESIS, ANALYSIS, TOXICITY SCREENING AND COMPUTATIONAL CHEMISTRY OF ARYLPHOSP

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项工作针对三个目标：1)引入本科理科专业从事有机和药物化学、物理生物化学、体内和体外毒性/活性筛选以及生物感兴趣分子的计算化学的研究，2)扩大罗德岛学院本科生的研究机会，3)在该学院和其他INBRE机构的物理和生物科学家之间开展合作研究。一个明确的直接结果是，拥有坚实研究基础的学生毕业，将为研究生学习或进入学士学位水平的生物技术工作做好准备。这项工作的一个可能的直接结果是针对癌症、神经疾病和细菌感染的新的治疗药物。连续成果指标是研究主任和学生在地方、区域和国家专业科学会议上的陈述。这项工作已经到了手稿准备提交同行审阅出版的阶段。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This work is directed towards three goals: 1) Introduction of undergraduate science majors to research in organic and medicinal chemistry, physical biochemistry, toxicity/activity screening in vivo and in vitro, and computational chemistry of biologically interesting molecules, 2) Expanding the research opportunities for undergraduates at Rhode Island College, and 3) Developing collaborative research among the physical and biological scientists at the college and at other INBRE institutions. A definite direct outcome is the graduation of students with a strong foundation in research that will prepare them for graduate study or entry into the biotechnology workforce at the bachelor's degree level. A possible direct outcome of this work is new therapeutic agents against cancer, neurological disease, and bacterial infection. Continuous outcome indicators are the presentations by research directors and students at local, regional and national professional sceintific meetings. The work has reached the stage that manuscripts are being prepared for submission to peer review for publication.