UKY DENTAL COBRE: ORAL INFECTIONS: COX-2

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 具体目标1：确定非选择性考克斯和选择性考克斯-2抑制对牙龈卟啉单胞菌诱导的小鼠血管疾病的影响。 具体目标2：明确12/15-脂氧合酶在牙龈卟啉单胞菌诱导的牙周病和动脉粥样硬化中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1:. Determine the effect of non-selective COX and selective COX-2 inhibition on P. gingivalis-induced vascular disease in mice. Specific Aim 2: Define the role of 12/15-lipoxygenases in P. gingivalis-induced periodontal disease and atherosclerosis.