UKY DENTAL COBRE: ORAL INFECTIONS: COX-2

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标1：。确定非选择性COX和选择性COX-2抑制对牙龈假单胞菌所致小鼠血管病变的影响。 具体目标2：明确12/15-脂氧合酶在牙周炎和动脉粥样硬化中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1:. Determine the effect of non-selective COX and selective COX-2 inhibition on P. gingivalis-induced vascular disease in mice. Specific Aim 2: Define the role of 12/15-lipoxygenases in P. gingivalis-induced periodontal disease and atherosclerosis.