Identification of functional antibodies that control Mycobacterium Tuberculosis

结核分枝杆菌感染了全球三分之一的人口，2015年新增结核病病例1020万例，死亡110万例。这项研究旨在从自然控制结核分枝杆菌感染的人中识别针对结核分枝杆菌的抗体，用于单抗治疗。我们还将确定诱导这些保护性抗体所需的免疫信号。最终，这项研究将指导未来结核疫苗、治疗和诊断工具的开发。

Mycobacterium tuberculosis (MTB) infects one third of the global population, with 10.2 million new cases of TB and 1.1 million million deaths in 2015. This study aims to identify antibodies that target MTB from people that naturally control MTB infection for use as monoclonal antibody therapeutics. We will also identify the immune signals required to induce these protective antibodies. Ultimately, this study will guide the development of future MTB vaccines, therapeutics and diagnostics tools.