MODELING MOTOR PROTEINS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们正在使用分子动力学模拟来研究与力和运动的产生相关的马达蛋白的构象变化。 我们正在研究运动蛋白肌球蛋白和肌动蛋白。 特别是，我们正在研究的变化，在相互作用的核苷酸与蛋白质的活性位点和并发的构象变化的马达蛋白。 相互作用是复杂的。 UCSF计算机图形实验室的支持对于我们分子动力学模拟结果的可视化和解释以及理解核苷酸和蛋白质之间的相互作用至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are using molecular dynamics simulations to study conformational changes in motor proteins associated with the generation of force and motion. We are studying the motor proteins myosin and actin. In particular, we are examining changes in the interactions of the nucleotide with the protein at the active site and the concurrent conformational changes in motor proteins. The interactions are complex. The support of the Computer Graphics Laboratory at UCSF is essential for visualization and interpretation of the results of our molecular dynamics simulations, and understanding the interplay between nucleotide and protein.