TG DAC: MONTE CARLO CALCULATION OF SYSTEM MATRIX FOR PET INSERT DEVICE FOR BREA

TG DAC：BREA 宠物插入装置系统矩阵的蒙特卡罗计算

• 批准号: 7723321
• 负责人: YUAN-CHUAN TAI
• 金额: $ 0.05万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723321
• 关键词: Breast; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Devices; Funding; Gamma Rays; Goals; Grant; Image; Institution; Modeling; Patients; Performance; Positron-Emission Tomography; Probability; Radioactivity; Research; Research Personnel; Resolution; Resources; Source; System; United States National Institutes of Health; base; computing resources; detector; image reconstruction; programs; reconstruction; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing a new type of PET (positron emission tomography) device for breast imaging applications that uses a high-resolution semi-circular ring of detectors within a conventional PET/CT scanner to zoom-in on the region around a breast to obtain high-resolution images. To aid the development of our system, we must perform realistic Monte Carlo simulations to understand the performance of our system and to generate a system matrix. A system matrix represents the probability of detecting a pair of gamma rays originated from a voxel in the imaging field of view. One can use the system matrix in a statistical iterative reconstruction framework to estimate the distribution of radioactivity in the patient. We have evaluated existing Monte Carlo simulation packages such as GATE, a Geant4-based simulation program, to perform this simulation study, but found that none of the existing software will handle our unique system geometry efficiently. We are developing our own simulation program that specifically models our geometry in an efficient fashion. We would like to evaluate the accuracy of our simulation program, and once done, generate the full system matrix, and perform image reconstruction using the Teragrid computing resources. To achieve these goals, we anticipate that we will need a full 30,000 SU development allocation.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在开发一种用于乳腺成像应用的新型PET（正电子发射断层扫描）设备，该设备使用传统PET/CT扫描仪内的高分辨率半圆形探测器环来放大乳腺周围区域以获得高分辨率图像。为了帮助我们的系统的发展，我们必须执行现实的蒙特卡罗模拟，以了解我们的系统的性能，并生成一个系统矩阵。系统矩阵表示检测到源自成像视场中的体素的一对伽马射线的概率。可以在统计迭代重建框架中使用系统矩阵来估计患者中的放射性分布。我们已经评估了现有的Monte Carlo模拟软件包，如GATE，一个基于Geant 4的模拟程序，来执行此模拟研究，但发现没有一个现有的软件将有效地处理我们独特的系统几何形状。我们正在开发我们自己的模拟程序，专门模拟我们的几何形状在一个有效的方式。我们希望评估我们的模拟程序的准确性，一旦完成，生成完整的系统矩阵，并使用Teragrid计算资源执行图像重建。为了实现这些目标，我们预计我们将需要一个完整的30,000 SU发展分配。