HIGH-RESOLUTION FMRI OF THE MEDIAL TEMPORAL LOBE DURING DELAYED-MATCH-TO-SAMPLE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 众所周知，内侧颞叶(MTL)对于对事件和事实的长期记忆至关重要。然而，最近使用短延迟任务范式的功能神经成像和神经心理学数据表明，即使在短暂的保持间隔之后，MTL也有助于提高成绩。此外，啮齿类动物的单个单位数据显示，在延迟-非匹配到样本任务的背景下，MTL中与性能相关的延迟活动。 具体目标： 在当前的研究中，使用高分辨率功能磁共振成像对健康成年人进行扫描，以探索人类MTL亚区在短延迟(30 S)延迟匹配到样本任务中对绩效的贡献。 方法和材料： 在一半的试验中，出现了两张脸(1张S)，然后是30张S的延迟，之后参与者遇到了两种选择的强迫选择探测(720次试验)。在试验的另一半，延迟时间为4个S。参与者在3T扫描仪上进行螺旋输入-输出粗体序列扫描。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: The medial temporal lobe (MTL) is known to be critical for long-term memory for events and facts. However, recent functional neuroimaging and neuropsychological data using short-delay task paradigms have suggested that the MTL contributes to performance even after brief retention intervals. Moreover, single-unit data in rodents have demonstrated performance-related delay activity in the MTL in the context of delayed-non-match-to-sample tasks. Specific Aims: In the current study, healthy adults were scanned using high-resolution functional MRI to explore the contributions of human MTL subregions to performance during a short-delay (30 s) delayed-match-to-sample task. Methods and Materials: On half of the trials, two faces were presented (1 s), followed by a 30-s delay, after which participants encountered a two-alternative forced choice probe (720 trials). On the other half of trials, the delay period was 4 s. Participants were scanned on a 3T-scanner using a spiral in-out BOLD sequence.