HIGH-RESOLUTION FMRI OF THE MEDIAL TEMPORAL LOBE DURING DELAYED-MATCH-TO-SAMPLE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: The medial temporal lobe (MTL) is known to be critical for long-term memory for events and facts. However, recent functional neuroimaging and neuropsychological data using short-delay task paradigms have suggested that the MTL contributes to performance even after brief retention intervals. Moreover, single-unit data in rodents have demonstrated performance-related delay activity in the MTL in the context of delayed-non-match-to-sample tasks. Specific Aims: In the current study, healthy adults were scanned using high-resolution functional MRI to explore the contributions of human MTL subregions to performance during a short-delay (30 s) delayed-match-to-sample task. Methods and Materials: On half of the trials, two faces were presented (1 s), followed by a 30-s delay, after which participants encountered a two-alternative forced choice probe (720 trials). On the other half of trials, the delay period was 4 s. Participants were scanned on a 3T-scanner using a spiral in-out BOLD sequence.