NOVEL PROTEIN-PROTEIN DOCKING TOOLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 蛋白质-蛋白质相互作用在酶复合体的形成、转录调控、离子通道调控以及许多基本的细胞过程中起着至关重要的作用。然而，目前用于计算方法的蛋白质-蛋白质相互作用算法在精度和速度上仍然受到限制。我们建议开发具有高级用户界面环境的新型蛋白质-蛋白质对接方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Protein-Protein interaction is critical in the formation of enzymatic complexes, transcriptional regulation, and ion channel regulations, and many essential cellular processes. However, current protein-protein interaction algorithms used in computational approaches are still limited in both accuracy and speed. We propose to develop novel protein-protein docking methods with an advanced user interface environment.