DYNAMICALLY CONTROLLED PROTEIN TUNNELING PATHS IN PHOTOSYNTH REACTION CENTERS

光合成反应中心动态控制的蛋白质隧道路径

• 批准号: 7722296
• 负责人: C KOBAYASHI
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722296
• 关键词: Azurin; Computer Retrieval of Information on Scientific Projects Database; Coupled; Electron Transport; Funding; Grant; Hybrids; Institution; Methods; Nuclear; Pathway interactions; Personal Satisfaction; Proteins; Publications; Reaction; Research; Research Personnel; Resources; Source; System; Testing; United States National Institutes of Health; Work; molecular dynamics; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Identification of new mechanism of nuclear dynamics amplification in proteins was established. New algorithmic capabilities were added to GAMESS in order to understand the electron transfer in these systems. Additionally, the new tools were coupled with molecular dynamics methods for the full analysis, creating a new hybrid tool capability. This was tested on test molecules as well as a small protein system, Azurin, in which the pathways have been well elucidated. This work resulted in a publication, and is now being used to establish a prediction of pathways in larger protein system where pathways are less understood.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 确定了蛋白质中核动力学扩增的新机制。为了了解这些系统中的电子传输，添加了新的算法功能。 此外，新工具还与分子动力学方法相结合，以进行完整分析，从而创造了新的混合工具能力。 这是在测试分子以及小蛋白质系统Azurin上测试的，其中途径已经很好地阐明了。 这项工作导致出版物，现在被用来在较大的蛋白质系统中建立途径的预测，而途径较少了解。