Procedures to Assess the Hazards of a Superfund Site

评估超级基金场地危害的程序

• 批准号: 7664692
• 负责人: Stephen H. Safe
• 金额: $ 40万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7664692
• 关键词: Adverse effects; Animals; Area; Basic Science; Binding; Biodegradation; Biological; Biological Markers; Biomedical Research; Biometry; Chemical Exposure; Chemicals; Collaborations; Complex; Complex Mixtures; Cultured Cells; Data; Development; Disease; Dose; Drug Metabolic Detoxication; Education and Outreach; Environment; Environmental Risk Factor; Exposure to; Genetic; Goals; Halogenated Hydrocarbons; Hazardous Waste Sites; Health; Human; Hydrocarbons; Image Analysis; International; Intervention; Knowledge; Life; Mediating; Metals; Methods; Modeling; Other Genetics; Population; Predisposition; Procedures; Process; Research; Research Project Grants; Research Support; Risk; Risk Assessment; Risk Factors; Risk Reduction; Services; Site; Support of Research; Techniques; Technology; Texas; Toxicology; Translating; Translational Research; Translations; Universities; disorder risk; fundamental research; hazard; human population study; improved; interest; novel; programs; receptor; remediation; response; superfund site

The overall theme of the Superfund Basic Research Program (SBRP) at Texas A&M University is to conduct fundamental research that will provide critical data to facilitate risk assessment and risk reduction of complex environmental mixtures. The results of these studies will be translated to knowledge that will improve scientific and public confidence in the overall process for the characterization and remediation of hazardous waste sites. Research projects and cores will generate information from cell culture, whole animal and human population studies to assess the health risks associated with exposure to complex mixtures. Research areas include mechanistic toxicology, susceptibility and predisposition, exposure assessment, and remediation. Chemicals of interest include complex mixtures of polycyclic aromatic hydrocarbons, halogenated hydrocarbons and metals. Five biomedical research projects will: (a) quantify contaminants in the environment and in human populations; (b) determine the underlying mechanisms responsible for environmentally-induced disease; and, (c) investigate the effects of genetic and environmental factors in the risk of disease. The two non-biomedical research projects will enhance procedures for reducing the risk from complex mixtures through either chemical intervention technologies or biodegradation. Results of basic research will be validated by translational research conducted at Superfund sites in collaboration with USEPA or state regulatory agencies, and in international populations living on contaminated sites. To support the research projects, the Program also includes three Research Support Cores (Image Analysis, Analytical Services & Biostatistics, and Field Services) and Administrative, Outreach, and Training Cores.

德克萨斯A&M大学超级基金基础研究计划(SBRP)的总体主题是进行 基础研究将提供关键数据，以促进复杂环境的风险评估和风险降低 环境混合物。这些研究的结果将被转化为将改善的知识 科学和公众对危险的定性和补救的整个进程的信心 废弃地。研究项目和核心将从细胞培养、整个动物和 人类人口研究，以评估与接触复杂混合物有关的健康风险。 研究领域包括机械毒理学、易感性和易感性、暴露评估和 补救措施。感兴趣的化学品包括多环芳烃的复杂混合物， 卤代烃和金属。五个生物医学研究项目将：(A)量化 在环境和人类人口中；(B)确定负责 环境引起的疾病；以及，(C)调查遗传和环境因素对 有患病的风险。这两个非生物医学研究项目将加强降低风险的程序。 通过化学干预技术或生物降解从复杂的混合物中分离出来。结果： 基础研究将通过与Superfund网站合作进行的翻译研究进行验证 美国环保局或州监管机构，以及生活在受污染地点的国际人口。至 除了支持研究项目外，该计划还包括三个研究支持核心(图像分析、 分析服务、生物统计和外勤服务)以及行政、外联和培训核心。