STIMULI-RESPONSIVE LIPOSOMES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在研究具有响应性的囊泡(直径约100 nm)，其形成囊泡的能力是通过化学反应(电子转移)来控制的。囊泡由磷脂和脂类(脂肪酸)组成，是小的单层囊泡。从光散射和场流分馏实验可以看出，它们在各种溶液条件下都能稳定数周。 我们需要用透射电子显微镜证明它们的形状和大小，但由于磷脂/脂类(电子受体)的性质，我们不能确定它们在透射电子显微镜下的稳定性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are working with responsive vesicles (~100 nm diameter) whose ability to form vesicles is manipulated via chemical reactions (electron transfer). The vesicles are composed of phospholipids and lipids (fatty acids) and are small unilamellar vesicles. They are stable for weeks under a variety of solution conditions, as noted from light scattering and field-flow fractionation expts. We need evidence of their shape and size using TEM, but are unsure of their stability in TEM due to the nature of the phospholipid/lipid (electron acceptor).