MECHANICS OF BLOOD FLOW IN MICROVESSELS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项关于超级计算机资源的提案是为了支持两项由国家科学基金资助的授予PI的提案(BES-0603035和CTS-0625936)。该方案的目的是开发计算流体动力学模型和模拟来研究可变形颗粒的流体动力学。重点将放在直径为10-300美元的微血管中的多个血细胞的血流动力学上，这是微循环和微流体设备的典型特征。重点是能够考虑大量可变形血细胞的动态，同时解决每个单独细胞的变形和内部流动。为此，我们正在使用NCSA的IBM p690开发全三维代码，使用变形单元的迭代边界方法，并将傅立叶-有限差分结合格式用于流动求解器。我们还通过一种简单的化学动力学方法将相邻细胞之间以及细胞和血管壁之间的分子相互作用与流体力学相结合。利用过去的分配，我们开发了3D程序，并解决了与微血管中单个和二元可变形细胞的流体力学有关的一些问题。我们继续对多个细胞进行研究，因此请求NCSA继续支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal for supercomputer resource is to support two NSF-funded proposals awarded to the PI (BES-0603035 and CTS-0625936). Objective of the proposal is to develop computational fluid dynamic models and simulation to study the hydrodynamics of deformable particles. The focus will be on the hemodynamics of multiple blood cells in microvessels of 10--300$\mu$m diameter, typical of microcirculation and microfluidic devices. The emphasis is on the ability to consider the dynamics of a large population of deformable blood cells, $\sim$ O(500) in number, while resolving the deformation of and the flow inside each individual cell. To that end, we are using the IBM p690 at NCSA to develop fully three-dimensional code using immsersed boundary methods for deformable cells, and combined Fourier--Finite difference scheme for the flow solver. We also couple molecular interaction between the adjacent cells and between a cell and a blood vessel wall to the hydrodynamics via a simple chemical kinetic approach. Using the past allocation, we have developed the 3D code, and addressed some problems related to the hydrodynamics of single and binary deformable cells in microvessels. We continue to pursue research on multiple cells, and hence request for continued support from NCSA.