MECHANICS OF BLOOD FLOW IN MICROVESSELS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal for supercomputer resource is to support two NSF-funded proposals awarded to the PI (BES-0603035 and CTS-0625936). Objective of the proposal is to develop computational fluid dynamic models and simulation to study the hydrodynamics of deformable particles. The focus will be on the hemodynamics of multiple blood cells in microvessels of 10--300$\mu$m diameter, typical of microcirculation and microfluidic devices. The emphasis is on the ability to consider the dynamics of a large population of deformable blood cells, $\sim$ O(500) in number, while resolving the deformation of and the flow inside each individual cell. To that end, we are using the IBM p690 at NCSA to develop fully three-dimensional code using immsersed boundary methods for deformable cells, and combined Fourier--Finite difference scheme for the flow solver. We also couple molecular interaction between the adjacent cells and between a cell and a blood vessel wall to the hydrodynamics via a simple chemical kinetic approach. Using the past allocation, we have developed the 3D code, and addressed some problems related to the hydrodynamics of single and binary deformable cells in microvessels. We continue to pursue research on multiple cells, and hence request for continued support from NCSA.