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PHLPP IN AUTOPHAGY

PHLPP IN AUTOPHAGY
PHPP 在自噬中的应用
批准号：
7722459
负责人：
ALEXANDRA C. NEWTON
金额：
$0.29万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-05-01 至 2009-04-30
来源：
https://reporter.nih.gov/project-details/7722459
关键词：
ApoptosisAutophagocytosisComputer Retrieval of Information on Scientific Projects DatabaseEtoposideFundingG-Protein-Coupled ReceptorsGrantGrowth FactorInstitutionPH DomainPhosphotransferasesProtein DephosphorylationProtein phosphataseResearchResearch PersonnelResourcesRoleSignal TransductionSiteSourceTSC2 geneTestingUnited States National Institutes of Healthleucine-rich repeat proteinresponse

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PH domain leucine-rich repeat protein phosphatase (PHLPP) terminates growth factor- and G-protein coupled receptor (GPCR)-induced signaling through dephosphorylation of the hydrophobic motif site in the carbolxyl-terminus the AGC kinases, Akt and PKC. PHLPP knockdown increases Akt activity towards a variety of substrates including TSC2, FOXO and GSK3 and reduces apoptosis in response to etoposide. We are currently testing the role of PHLPP in autophagy.
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