BRAIN IMAGING IN ALTITUDE ILLNESS

高原疾病的脑成像

• 批准号: 7724354
• 负责人: ROBERT C ROACH
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724354
• 关键词: Acute; Altitude; Altitude Sickness; Blood - brain barrier anatomy; Blood Plasma Volume; Blood Volume; Brain; Brain Edema; Brain imaging; Cerebral perfusion pressure; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Drops; Exercise; Functional disorder; Funding; Genotype; Goals; Grant; Heat-Shock Response; Human; Hypoxia; Institution; Intracranial Pressure; Liquid substance; Magnetic Resonance Imaging; Measurement; Molecular Genetics; Nitric Oxide; Oxygen; Peptidyl-Dipeptidase A; Permeability; Physiological; Production; Research; Research Personnel; Resources; Role; Severities; Source; Study of magnetics; Symptoms; United States National Institutes of Health; Vascular Endothelial Growth Factors; Water; extracellular; innovation; innovative technologies; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'The goal of this proposal is to determine the role of brain swelling in the pathophysiology of acute mountain sickness (AMS). We recently showed that exercise caused a >3 fold rise in AMS symptom severity, a drop in arterial oxygen saturation (SaO2) during exercise, and slight fluid retention. We also recently showed that subjects ill with AMS had a small drop in plasma volume and a large rise in extracellular water compared to those that remained free of AMS. In further studies, magnetic resonance imaging revealed that most brains swell when humans ascend to high altitude. Our overall hypothesis is that brain swelling, which can include elevated brain water and blood volume, causes the symptoms of AMS. Our approach is to use several new and innovative technologies to dissect the role of cellular, molecular, genetic and physiological responses in the pathophysiology of AMS. The new and innovative approaches include measurement in humans acutely deprived of oxygen of 1) nitric oxide (NO) production; 2) vascular endothelial growth factor (VEGF); 3) heat shock factor/heat shock protein72 (HSF/HSP72); and 4) angiotensin converting enzyme (ACE) genotype. We will also make the first noninvasive measurements of cerebral perfusion pressure (eCPP), intracranial pressure (eICP), cerebral blood volume (CBV), blood-brain barrier (BBB) permeability, brain water and craniospinal volumes in humans exposed to acute hypoxia for 9 hrs.

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