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STAFF INVESTIGATORS

调查人员

基本信息

批准号：
7529350
负责人：
AFSHIN DOWLATI
金额：
$ 6.35万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-06 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7529350
关键词：
American Society of Clinical Oncology Angiogenesis Inhibitors Antineoplastic Agents Archives Area Award B-Lymphocytes Biological Markers Biopsy Breast Cells Chairperson Cisplatin Clinic Clinical Clinical Investigator Clinical Research Clinical Trials Clinical Trials Design Combination Chemotherapy Correlative Study Data Development Developmental Therapeutics Program Diagnosis Diffuse Disease Disease-Free Survival Drug Kinetics Eastern Cooperative Oncology Group End Point Epidermal Growth Factor Receptor Etoposide Extensive Stage FCGR3B gene Follicular Lymphoma Funding Genes Genetic Polymorphism Guidelines Hematologic Neoplasms Hematology Hodgkin Disease Immune response Immunohistochemistry International Joints K-Series Research Career Programs Laboratories Leadership Limited Stage Lung Lymphoma MS4A1 gene Malignant Neoplasms Malignant neoplasm of lung Medicine Medlone 21 Mentored Clinical Oncology Award Mentored Clinical Scientist Award Mentored Patient-Oriented Research Career Development Award Methods Molecular Molecular Profiling Monoclonal Antibodies Monoclonal Antibody Therapy Multidrug Resistance Gene Non-Hodgkin&apos s Lymphoma Operative Surgical Procedures Oral Outcome Participant Pathway interactions Patients Peripheral Pharmaceutical Preparations Pharmacology Shared Resource Phase Phase I Clinical Trials Phase I/II Trial Phase II Clinical Trials Population Predictive Factor Predictive Value Principal Investigator Prior Therapy Prognostic Factor Protein Tyrosine Kinase Radiation Radioimmunotherapy Refractory Relapse Research Research Activity Research Design Research Personnel Research Project Grants Retrospective Studies Role STAT3 gene Science Southwest Oncology Group Staging Stem cell transplant Stem cells T-Cell Lymphoma T-Lymphocyte Testing Therapeutic Time Tissue Microarray Tissues Translating Translational Research Translational Research Shared Resource Vascular Endothelial Growth Factors Work authority base bevacizumab cancer pharmacology chemotherapy clinical effect concept design drug development gemcitabine improved inhibitor/antagonist lapatinib lung small cell carcinoma lymph nodes macrophage member model development novel novel therapeutics oncology professor programs protocol development quality assurance response rituximab tositumomab translational study tumorigenesis

项目摘要

Two staff investigators are proposed, both to serve in the function as Deputy Associate Directors for Clinical Research. Dr. Afshin Dowlati, an expert in novel therapeutic development in lung cancer, and Dr. John Sweetenham, an expert in lymphoma therapeutics, are both accomplished clinical investigators with considerable leadership capacity to coordinate clinical trials research emphasizing investigator-initiated efforts. As staff investigators, they will have focused time to devote to clinical trials development and oversight with special emphasis on investigator-initiated trials that cut across scientific programs and involve the Case CCC clinical trials disease teams. As staff investigators, they will have the prominence and authority to assist investigators in protocol development and design, and in efficient, safe management with a high degree of quality assurance during early phase drug development.

提议两名工作人员调查员担任临床副副主任研究。肺癌新疗法开发专家Afshin Dowlati博士和John博士斯威特纳姆是淋巴瘤治疗方面的专家，两人都是经验丰富的临床研究人员具有相当强的领导能力，能够协调临床试验研究，强调由研究人员发起努力。作为工作人员研究员，他们将有集中的时间致力于临床试验的开发和监督，特别强调研究人员发起的试验，这些试验跨越科学计划，涉及病例ccc临床试验疾病团队。作为工作人员调查员，他们将有突出的地位和授权协助调查人员制定和设计协议，并通过以下方式进行高效、安全的管理在药物开发的早期阶段有高度的质量保证。