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Giardia drug targets: Structure, function and inhibitors

Giardia drug targets: Structure, function and inhibitors
贾第鞭毛虫药物靶点：结构、功能和抑制剂
批准号：
8133261
负责人：
OSNAT HERZBERG
金额：
$71.35万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
项目状态：
已结题
起止时间：
2005-02-01 至 2012-08-31
来源：
https://reporter.nih.gov/project-details/8133261
关键词：
ADME StudyActive SitesAdverse effectsAffectAffinityAldehyde-LyasesAnimalsArginineArginine deiminaseBindingBiological AssayBiotechnologyBioterrorismCarbamatesCategoriesCellsCenters for Disease Control and Prevention (U.S.)Cessation of lifeChemicalsChildChronicClinicalCollaborationsCountryDegradation PathwayDevelopmentDiarrheaDiseaseDisease OutbreaksDrug Delivery SystemsDrug resistanceDrug usageEnzyme Inhibitor DrugsEnzyme InhibitorsEnzymesEvaluationFood SupplyFructoseFructosediphosphate AldolaseGenomicsGiardiaGiardia lambliaGiardiasisGoalsGrowthHeadHistone DeacetylaseHistone Deacetylase InhibitorHomologous GeneHumanImmunocompetentImmunocompromised HostIn VitroInfectionInstitutesKineticsLaboratoriesLeadLettersLibrariesMalnutritionMarylandMetabolicMetronidazoleNew MexicoOrganismParasitesPathway interactionsPatientsPharmaceutical ChemistryPharmaceutical PreparationsPhasePhosphotransferasesProcessProductionPropertyProteinsRNA InterferenceRecurrenceResistanceRoentgen RaysScreening procedureSideStructureTechniquesTestingTherapeuticTherapeutic AgentsToxic effectTranscriptional RegulationTrichostatin AUnited StatesUnited States National Institutes of HealthUniversitiesWaterWorld Health Organizationalternative treatmentbasecytotoxicitydesignenzyme mechanismenzyme pathwayfoodbornegenetic manipulationhigh throughput screeningin vitro testingin vivoinhibitor/antagonistinsightkillingskinase inhibitormedical schoolsmultidisciplinaryneglectnovelnovel therapeuticsresistant strainstructural genomicswaterborne

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期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Crystal structures of carbamate kinase from Giardia lamblia bound with citric acid and AMP-PNP.
DOI： 10.1371/journal.pone.0064004
发表时间： 2013
期刊： PloS one
影响因子： 3.7
作者： [Lim K, Kulakova L, Galkin A, Herzberg O]
通讯作者： Herzberg O
A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase.
DOI： 10.2174/1875397301206010093
发表时间： 2012
期刊： Current chemical genomics
影响因子： --
作者： [Chen CZ, Southall N, Galkin A, Lim K, Marugan JJ, Kulakova L, Shinn P, van Leer D, Zheng W, Herzberg O]
通讯作者： Herzberg O
Fumagillin Derivatives as Novel Antigiardiasis and Antiamebiasis Drugs
  • 批准号：
    9089862
  • 项目类别：
  • 资助金额：
    $20.9万
  • 财政年份：
    2015
  • 负责人：
    OSNAT HERZBERG
  • 依托单位：
    UNIV OF MARYLAND, COLLEGE PARK
Fumagillin Derivatives as Novel Antigiardiasis and Antiamebiasis Drugs
  • 批准号：
    8960227
  • 项目类别：
  • 资助金额：
    $20.9万
  • 财政年份：
    2015
  • 负责人：
    OSNAT HERZBERG
  • 依托单位：
    UNIV OF MARYLAND, COLLEGE PARK
Identification and in vitro experimental investigation of missense SNPs implicate
  • 批准号：
    8366038
  • 项目类别：
  • 资助金额：
    $28.88万
  • 财政年份：
    2012
  • 负责人：
    OSNAT HERZBERG
  • 依托单位：
    UNIV OF MARYLAND, COLLEGE PARK
Identification and in vitro experimental investigation of missense SNPs implicate
  • 批准号：
    8534208
  • 项目类别：
  • 资助金额：
    $27.87万
  • 财政年份：
    2012
  • 负责人：
    OSNAT HERZBERG
  • 依托单位：
    UNIV OF MARYLAND, COLLEGE PARK
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