Giardia drug targets: Structure, function and inhibitors

贾第鞭毛虫药物靶点：结构、功能和抑制剂

• 批准号: 8133261
• 负责人: OSNAT HERZBERG
• 金额: $ 71.35万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8133261
• 关键词: ADME Study; Active Sites; Adverse effects; Affect; Affinity; Aldehyde-Lyases; Animals; Arginine; Arginine deiminase; Binding; Biological Assay; Biotechnology; Bioterrorism; Carbamates; Categories; Cells; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chemicals; Child; Chronic; Clinical; Collaborations; Country; Degradation Pathway; Development; Diarrhea; Disease; Disease Outbreaks; Drug Delivery Systems; Drug resistance; Drug usage; Enzyme Inhibitor Drugs; Enzyme Inhibitors; Enzymes; Evaluation; Food Supply; Fructose; Fructosediphosphate Aldolase; Genomics; Giardia; Giardia lamblia; Giardiasis; Goals; Growth; Head; Histone Deacetylase; Histone Deacetylase Inhibitor; Homologous Gene; Human; Immunocompetent; Immunocompromised Host; In Vitro; Infection; Institutes; Kinetics; Laboratories; Lead; Letters; Libraries; Malnutrition; Maryland; Metabolic; Metronidazole; New Mexico; Organism; Parasites; Pathway interactions; Patients; Pharmaceutical Chemistry; Pharmaceutical Preparations; Phase; Phosphotransferases; Process; Production; Property; Proteins; RNA Interference; Recurrence; Resistance; Roentgen Rays; Screening procedure; Side; Structure; Techniques; Testing; Therapeutic; Therapeutic Agents; Toxic effect; Transcriptional Regulation; Trichostatin A; United States; United States National Institutes of Health; Universities; Water; World Health Organization; alternative treatment; base; cytotoxicity; design; enzyme mechanism; enzyme pathway; foodborne; genetic manipulation; high throughput screening; in vitro testing; in vivo; inhibitor/antagonist; insight; killings; kinase inhibitor; medical schools; multidisciplinary; neglect; novel; novel therapeutics; resistant strain; structural genomics; waterborne

项目成果

Crystal structures of carbamate kinase from Giardia lamblia bound with citric acid and AMP-PNP.

• DOI: 10.1371/journal.pone.0064004
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Lim K;Kulakova L;Galkin A;Herzberg O
• 通讯作者: Herzberg O

A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase.

• DOI: 10.2174/1875397301206010093
• 发表时间: 2012
• 期刊: Current chemical genomics
• 作者: Chen CZ;Southall N;Galkin A;Lim K;Marugan JJ;Kulakova L;Shinn P;van Leer D;Zheng W;Herzberg O
• 通讯作者: Herzberg O